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  3. SBP-0636457

SBP-0636457 (Synonyms: SBI-0636457; SB1-0636457)

Cat. No.: HY-125378
Handling Instructions

SBP-0636457 (SB1-0636457) is a SMAC mimetic, and as an IAP antagonist. SBP-0636457 binds to the BIR-domains of the IAP proteins, with a Ki of 0.27 μM. SBP-0636457 can be used for the research of solid tumors and hematologic cancers.

For research use only. We do not sell to patients.

SBP-0636457 Chemical Structure

SBP-0636457 Chemical Structure

CAS No. : 1422180-49-1

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Description

SBP-0636457 (SB1-0636457) is a SMAC mimetic, and as an IAP antagonist. SBP-0636457 binds to the BIR-domains of the IAP proteins, with a Ki of 0.27 μM. SBP-0636457 can be used for the research of solid tumors and hematologic cancers[1][2].

IC50 & Target[1]

XIAP

0.27 μM (Ki)

In Vitro

SBP-0636457 (1-20 μM) demonstrates no cytotoxicity in BT474, BT549, MCF7, and MDA-MB-231 breast cancer cell lines up to a concentration of 20μM[1].
SBP-0636457 (10-1000 nM; 20 h) is efficacious as TRAIL-sensitizing agents in MDA-MB-231 cells, with an EC50 of 9 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

456.58

Formula

C₂₅H₃₆N₄O₄

CAS No.

1422180-49-1

SMILES

O=C([[email protected]@H]1C(C)(C)C[[email protected]](N21)([H])OCC[[email protected]](NC([[email protected]@H](NC)C)=O)C2=O)N[[email protected]@H]3CCCC4=C3C=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

SBP-0636457SBI-0636457 SB1-0636457SBP0636457SBP 0636457SBI0636457SBI 0636457IAPSMACmimeticBIR-domainstumourshematologiccancersInhibitorinhibitorinhibit

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Product Name:
SBP-0636457
Cat. No.:
HY-125378
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