PBX-7016
Based on 1 Customer Validation
PBX-7016 is a Camptothecin (HY-16560) derivative. PBX-7016 can selectively inhibit Topoisomerase 1. PBX-7016 can specifically bind and degrade the cancer protein DDX5, thereby down-regulating the expression of anti-apoptotic proteins such as Survivin, Mcl-1, and XIAP, and promoting the apoptosis of cancer cells. PBX-7016 can be used to synthesis of ADCs.
For research use only. We do not sell to patients.
- CAS No.: 3003834-34-9
- Formula: C27H25N3O8
- Molecular Weight:519.50
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Topoisomerase Isoforms
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Biological Activity
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Topoisomerase I |
Mcl-1 |
XIAP |
Chemical Information
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CAS No. 3003834-34-9
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Appearance Solid
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Molecular Weight 519.50
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Formula C27H25N3O8
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Color Off-white to light yellow
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SMILES
C[C@@H](O)C(N[C@@H]1C2=C3C(CC1)=C4C(OCO4)=CC3=NC5=C2CN6C5=CC7=C(COC([C@]7(O)CC)=O)C6=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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