3040940-61-9
Chemical Structure
Topo I/DDX5-IN-1
- CAS No.: 3040940-61-9
- Formula:C28H19F3N2O7
- Molecular Weight:552.45
InChIKey: JTSYDPPKSIFUKF-MHZLTWQESA-N
SMILES: O=C(OCC1=C2C=C3C4=NC5=CC6=C(C=C5C(C7=CC(F)=CC(OC)=C7)=C4CN3C1=O)OC(F)(F)O6)[C@@]2(CC)O
Biological Activity: Topo I/DDX5-IN-1 (Compound A10) is a Topo I and DDX5 inhibitor. Topo I/DDX5-IN-1 inhibits Topo I activity, binds to DDX5, and suppresses DDX5 function. Topo I/DDX5-IN-1 increases expression of γ-H2AX and p21, suppresses the expression of antiapoptotic proteins (Bcl-2 and XIAP), stimulates ROS generation, and triggers Apoptosis. Topo I/DDX5-IN-1 exhibits anticancer activity against pancreatic cancer, non-small cell lung cancer, skin cancer, and colorectal cancer[1].
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Topo I/DDX5-IN-1 | Topo I/DDX5-IN-1 (Compound A10) is a Topo I and DDX5 inhibitor. Topo I/DDX5-IN-1 inhibits Topo I activity, binds to DDX5, and suppresses DDX5 function. Topo I/DDX5-IN-1 increases expression of γ-H2AX and p21, suppresses the expression of antiapoptotic proteins (Bcl-2 and XIAP), stimulates ROS generation, and triggers Apoptosis. Topo I/DDX5-IN-1 exhibits anticancer activity against pancreatic cancer, non-small cell lung cancer, skin cancer, and colorectal cancer. | |||||||||||||||||||||
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