Topo I/DDX5-IN-1
Topo I/DDX5-IN-1 (Compound A10) is a Topo I and DDX5 inhibitor. Topo I/DDX5-IN-1 inhibits Topo I activity, binds to DDX5, and suppresses DDX5 function. Topo I/DDX5-IN-1 increases expression of γ-H2AX and p21, suppresses the expression of antiapoptotic proteins (Bcl-2 and XIAP), stimulates ROS generation, and triggers Apoptosis. Topo I/DDX5-IN-1 exhibits anticancer activity against pancreatic cancer, non-small cell lung cancer, skin cancer, and colorectal cancer.
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- CAS No.: 3040940-61-9
- Formule: C28H19F3N2O7
- Masse moléculaire:552.45
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Activité biologique
Description
IC50 & Target
[1]|
Topoisomerase I |
Bcl-2 |
XIAP |
Chemical Information
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CAS No. 3040940-61-9
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Masse moléculaire 552.45
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Formule C28H19F3N2O7
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SMILES
O=C(OCC1=C2C=C3C4=NC5=CC6=C(C=C5C(C7=CC(F)=CC(OC)=C7)=C4CN3C1=O)OC(F)(F)O6)[C@@]2(CC)O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Topo I/DDX5-IN-1 Related Classifications
HY-181018 Related Classifications
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