Topo I/DDX5-IN-1
Topo I/DDX5-IN-1 (Compound A10) is a Topo I and DDX5 inhibitor. Topo I/DDX5-IN-1 inhibits Topo I activity, binds to DDX5, and suppresses DDX5 function. Topo I/DDX5-IN-1 increases expression of γ-H2AX and p21, suppresses the expression of antiapoptotic proteins (Bcl-2 and XIAP), stimulates ROS generation, and triggers Apoptosis. Topo I/DDX5-IN-1 exhibits anticancer activity against pancreatic cancer, non-small cell lung cancer, skin cancer, and colorectal cancer.
For research use only. We do not sell to patients.
- CAS No.: 3040940-61-9
- Formula: C28H19F3N2O7
- Molecular Weight:552.45
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All Topoisomerase Isoforms
More
Biological Activity
|
Topoisomerase I |
Bcl-2 |
XIAP |
Chemical Information
-
CAS No. 3040940-61-9
-
Molecular Weight 552.45
-
Formula C28H19F3N2O7
-
SMILES
O=C(OCC1=C2C=C3C4=NC5=CC6=C(C=C5C(C7=CC(F)=CC(OC)=C7)=C4CN3C1=O)OC(F)(F)O6)[C@@]2(CC)O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Topo I/DDX5-IN-1 Related Classifications
HY-181018 Related Classifications
Powered by Bioz