2. Apoptosis Metabolic Enzyme/Protease
  3. MDM-2/p53 IAP E1/E2/E3 Enzyme
  4. MX69

MX69 

Cat. No.: HY-100892 Purity: 99.60%
COA Handling Instructions

MX69 is an inhibitor of MDM2/XIAP, used for cancer treatment.

For research use only. We do not sell to patients.

MX69 Chemical Structure

MX69 Chemical Structure

CAS No. : 1005264-47-0

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 94 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 94 In-stock
Solid
5 mg USD 90 In-stock
10 mg USD 150 In-stock
25 mg USD 290 In-stock
50 mg USD 470 In-stock
100 mg USD 750 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

MX69 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE MX69

View All IAP Isoform Specific Products:

View All Isoforms
cIAP cIAP-1 cIAP-2 XIAP

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

MX69 is an inhibitor of MDM2/XIAP, used for cancer treatment.

In Vitro

MX69 blocks the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation. MX69 shows minimal inhibitory effect on normal human hematopoiesis in vitro and is very well tolerated in animal models. MX69-induced MDM2 downregulation results not only in inhibition of XIAP expression, but also in activation of p53, which contributes to cancer cell apoptosis in vitro[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MX69 Related Antibodies
In Vivo

MX69-induced MDM2 downregulation results in activation of p53 which contributes to inhibition of cancer cell proliferation in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

474.57

Appearance

Solid

Formula

C27H26N2O4S
CAS No.
SMILES

O=C(O)C1=CC=C(C2C(CC=C3)C3C(C=C(S(=O)(NC4=CC(C)=C(C)C=C4)=O)C=C5)=C5N2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (210.72 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1072 mL 10.5359 mL 21.0717 mL
5 mM 0.4214 mL 2.1072 mL 4.2143 mL
10 mM 0.2107 mL 1.0536 mL 2.1072 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (5.27 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.27 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.27 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.60%

COA (250 KB) LCMS (97 KB)

Handling Instructions (2659 KB)
References
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MX69 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

MX691005264-47-0MX 69MX-69MDM-2/p53IAPE1/E2/E3 EnzymeE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseInhibitorinhibitorinhibit

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