1. Apoptosis
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  3. ASTX660

ASTX660 

Cat. No.: HY-109565 Purity: 99.01%
Handling Instructions

ASTX660 is an orally bioavailable dual antagonist of cellular inhibitor of apoptosis protein (cIAP) and X-linked inhibitor of apoptosis protein (XIAP).

For research use only. We do not sell to patients.

ASTX660 Chemical Structure

ASTX660 Chemical Structure

CAS No. : 1799328-86-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 1057 In-stock
Estimated Time of Arrival: December 31
5 mg USD 890 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

ASTX660 is an orally bioavailable dual antagonist of cellular inhibitor of apoptosis protein (cIAP) and X-linked inhibitor of apoptosis protein (XIAP).

IC50 & Target

cIAP, XIAP[1]

In Vitro

ASTX660 is an orally bioavailable dual antagonist of cIAP and XIAP, currently being investigated in a single-agent Phase 1/2 clinical trial in patients with advanced solid tumors and lymphomas. Twenty-one triple-negative breast cancer (TNBC) cell lines are treated with ASTX660 in vitro and it is found that 43% are sensitive to ASTX660[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In HCC1806 xenografts in mice, ASTX660 (daily oral treatment) causes moderate tumor growth inhibition but not regression[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

539.68

Formula

C₃₀H₄₂FN₅O₃

CAS No.

1799328-86-1

SMILES

C[[email protected]]1N(C[[email protected]@H]2N(CC(N3CC(C)(C)C4=NC(CO)=C(CC5=CC=C(F)C=C5)C=C43)=O)C[[email protected]@H](C)NC2)CCOC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (92.65 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8529 mL 9.2647 mL 18.5295 mL
5 mM 0.3706 mL 1.8529 mL 3.7059 mL
10 mM 0.1853 mL 0.9265 mL 1.8529 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.63 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.63 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.63 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.01%

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Keywords:

ASTX660ASTX 660ASTX-660IAPInhibitorinhibitorinhibit

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