2. Recombinant Proteins
  3. Enzymes & Regulators Kinases
  4. Transferases (EC 2) Serine/Threonine Kinase Proteins AGC
  5. NDR
  6. STK38/NDR1
  7. NDR1 Protein, Human (Active, sf9, GST)

NDR1 Protein, Human (Active, sf9, GST) is the recombinant human-derived NDR1, expressed by Sf9 insect cells , with GST labeled tag.

For research use only. We do not sell to patients.

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Description

NDR1 Protein, Human (Active, sf9, GST) is the recombinant human-derived NDR1, expressed by Sf9 insect cells , with GST labeled tag.
Background

NDR1 is a serine/threonine-protein kinase that functions as a negative regulator of MAP3K1/2 signaling. It converts MAP3K2 from its phosphorylated form to the non-phosphorylated state and inhibits MAP3K2 autophosphorylation. Additionally, NDR1 acts as a ufmylation 'reader' in a kinase-independent manner by specifically recognizing and binding mono-ufmylated histone H4 during DNA damage response, facilitating the recruitment of SUV39H1 to double-strand breaks to activate ATM.
Species

Human
Source

Sf9 insect cells
Tag

GST
Accession

Q15208 (M1-K465)
Gene ID

11329
Protein Length

Full Length
Synonyms
NDR; STK38
AA Sequence

MAMTGSTPCSSMSNHTKERVTMTKVTLENFYSNLIAQHEEREMRQKKLEKVMEEEGLKDEEKRLRRSAHARKETEFLRLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEWEHRIGAPGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTSNFDEFPESDILKPTVATSNHPETDYKNKDWVFINYTYKRFEGLTARGAIPSYMKAAK

Predicted Molecular Mass
81 kDa
Purity

≥ 80%, as determined by reducing SDS-PAGE.
Documentation
Handling Instructions (2659 KB)

NDR1 Protein, Human (Active, sf9, GST) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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