LY5

Cat. No.: HY-12442: FAQs
Data Sheet Handling Instructions

Molarity Calculator

LY5 is a STAT3 inhibitor with an IC₅₀ value of 0.5 μM. LY5 induces apoptosis and inhibits STAT3 phosphorylation. LY5 shows antitumor activity in vivo, it can be used for the research of cancer.

For research use only. We do not sell to patients.

LY5 Chemical Structure

CAS No. : 1436382-03-4

Size	Price	Stock
5 mg	USD 190	Ask For Quote & Lead Time
10 mg	USD 320	Ask For Quote & Lead Time
25 mg	USD 680	Ask For Quote & Lead Time
50 mg	USD 1150	Ask For Quote & Lead Time

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All STAT Isoform Specific Products:

View All Isoforms

STAT3 STAT5 STAT6 STAT1

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

IC50: 0.5 μM (STAT3)^[1]

In Vitro

LY5 shows inhibition effects to U2OS, RH30 and RD2 cancer cells with IC₅₀ values of 0.52, 0.55 and 1.39 μM, respectively^[1].
LY5 (0.25-1 μM; 16 h) induces apoptosis and inhibits STAT3 phosphorylation in human sarcoma cancer cells^[1].
LY5 (0.25-1 μM; 5 h) inhibits STAT3 phosphorylation induced by IL-6^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	RH30 and EW8 cell lines
Concentration:	0.25-1 μM
Incubation Time:	16 hours
Result:	Completely inhibited Tyr705 phosphorylation at 0.5 μM and dose-dependently decreased in formation of P-STAT3.

In Vivo

LY5 (5 mg/kg; i.p. once daily for 21 days) inhibits breast tumor growth in vivo^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Nude mice with MDA-MB-231 cancer cells injection^[1]
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection; 5 mg/kg; once daily; for 21 days
Result:	Suppressed tumor growth and significantly reduced the tumor sizes.

Molecular Weight

329.33

Formula

C₁₅H₁₁N₃O₄S

CAS No.

1436382-03-4

SMILES

NS(=O)(C1=C2C(C(C(NC3=CC=CN=C3)=CC2=O)=O)=CC=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yu W, et al. Discovery of novel STAT3 small molecule inhibitors via in silico site-directed fragment-based drug design. J Med Chem. 2013 Jun 13;56(11):4402-12. [Content Brief]

LY5 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LY51436382-03-4LY 5LY-5STATApoptosisapoptosisphosphorylationantitumorcancerU2OSRH30RD2IL-6miceInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks