1. JAK/STAT Signaling
    Stem Cell/Wnt
  2. STAT
  3. FLLL32

FLLL32 

Cat. No.: HY-100544 Purity: 99.78%
Handling Instructions

FLLL32 is a STAT3 inhibitor derived from the natural product curcumin. FLLL32 retains the cellular response to cytokines with anti-tumor activity.

For research use only. We do not sell to patients.

FLLL32 Chemical Structure

FLLL32 Chemical Structure

CAS No. : 1226895-15-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 77 In-stock
Estimated Time of Arrival: December 31
5 mg USD 70 In-stock
Estimated Time of Arrival: December 31
10 mg USD 100 In-stock
Estimated Time of Arrival: December 31
25 mg USD 150 In-stock
Estimated Time of Arrival: December 31
50 mg USD 250 In-stock
Estimated Time of Arrival: December 31
100 mg USD 450 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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  • References

Description

FLLL32 is a STAT3 inhibitor derived from the natural product curcumin. FLLL32 retains the cellular response to cytokines with anti-tumor activity[1].

IC50 & Target

STAT3[1]

In Vitro

FLLL32 specifically reduces STAT3 phosphorylation at Tyr705 (pSTAT3) and induces apoptosis at micromolar amounts in human melanoma cell lines and primary melanoma cultures[1].

Storage

4°C, protect from light

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (269.08 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1526 mL 10.7631 mL 21.5262 mL
5 mM 0.4305 mL 2.1526 mL 4.3052 mL
10 mM 0.2153 mL 1.0763 mL 2.1526 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.48 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

464.55

Formula

C₂₈H₃₂O₆

CAS No.

1226895-15-3

SMILES

O=C(C1(C(/C=C/C2=CC=C(OC)C(OC)=C2)=O)CCCCC1)/C=C/C3=CC=C(OC)C(OC)=C3

Shipping

Room temperature in continental US; may vary elsewhere

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Inquiry Information

Product Name:
FLLL32
Cat. No.:
HY-100544
Quantity:

FLLL32

Cat. No.: HY-100544