Sarilumab
Based on 1 Customer Validation
Sarilumab is a monoclonal antibody targeting IL6 that binds to IL6R and blocks the binding of IL6, thereby inhibiting the activation of the downstream STAT3 phosphorylation signaling pathway. In tumor cells with active IL6/STAT3 signaling pathways, Sarilumab induces Apoptosis and inhibits cell growth. Sarilumab is applicable to research related to prostate cancer, lung cancer and rheumatoid arthritis.
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- Purity: 99.36%
- CAS No.: 1189541-98-7
- 분자량:144.12 kDa
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
Human IgG1(D356E/L358M) kappa
Human
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IL-6 |
p-STAT3 |
Sarilumab blocks basal STAT3 phosphorylation in DU145, Calu3 and A549 human tumor cell lines with autocrine IL6/STAT3 signaling pathway in vitro, and exerts inhibitory effects on cell lines exhibiting autocrine IL6/STAT3 signaling[1].
Sarilumab enhances tumor cell apoptosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG1 kappa
ELISA, FACS, Functional assay
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Immobilized IL-6R alpha Protein, Human can bind Sarilumab. The EC50 for this effect is 34.98 ng/mL.
Chemical Information
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CAS No. 1189541-98-7
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Appearance Liquid
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분자량 144.12 kDa
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Color Colorless to light yellow
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SMILES
[Sarilumab]
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Synonyms
Anti-Human IL6Rα, Human Antibody
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선적
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
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Data Sheet (257 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sarilumab Related Classifications
HY-P9916 Related Classifications
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