1189541-98-7
1189541-98-7
Chemical Structure
Sarilumab
Synonym(s): Anti-Human IL6Rα, Human Antibody
- CAS No.: 1189541-98-7
- Formula:N/A
- Molecular Weight:(144.12 kDa)
SMILES: [Sarilumab]
Biological Activity: Sarilumab is a monoclonal antibody targeting IL6 that binds to IL6R and blocks the binding of IL6, thereby inhibiting the activation of the downstream STAT3 phosphorylation signaling pathway. In tumor cells with active IL6/STAT3 signaling pathways, Sarilumab induces Apoptosis and inhibits cell growth. Sarilumab is applicable to research related to prostate cancer, lung cancer and rheumatoid arthritis[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Sarilumab | 99.36% | Sarilumab is a monoclonal antibody targeting IL6 that binds to IL6R and blocks the binding of IL6, thereby inhibiting the activation of the downstream STAT3 phosphorylation signaling pathway. In tumor cells with active IL6/STAT3 signaling pathways, Sarilumab induces Apoptosis and inhibits cell growth. Sarilumab is applicable to research related to prostate cancer, lung cancer and rheumatoid arthritis. | ||||||||||||||||||||
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References
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[1]. Li Zhang, et al. Sarilumab (REGN88), a fully-human anti-IL6R antibody, inhibits tumor growth in preclinical models, as a single agent and in combination with the VEGF blocker
aflibercept. Cancer Res (2012) 72 (8_Supplement): 2723. - [2]. McCarty D, et al. Efficacy and safety of sarilumab in patients with active rheumatoid arthritis. Ther Adv Musculoskelet Dis. 2018 Mar;10(3):61-67. [Content Brief]
Keywords
