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  3. B022

B022 

Cat. No.: HY-120501
Handling Instructions

B022 is a potent and selective NF-κB-inducing kinase (NIK) inhibitor with a Ki of 4.2 nM. B022 protects liver from toxin-induced inflammation, oxidative stress, and injury.

For research use only. We do not sell to patients.

B022 Chemical Structure

B022 Chemical Structure

CAS No. : 1202764-53-1

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Description

B022 is a potent and selective NF-κB-inducing kinase (NIK) inhibitor with a Ki of 4.2 nM. B022 protects liver from toxin-induced inflammation, oxidative stress, and injury[1].

IC50 & Target

Ki: 4.2 nM (NF-κB-inducing kinase (NIK))[1]

In Vitro

B022 (0-5 μM; 12 hours; Hepa1 cells) treatment suppresses NIK-induced p52 formation in a dose-dependent manner[1].
B022 (0-5 μM; 12 hours; Hepa1 cells) treatment for 8 h completely blocks NIK-induced expression of TNF-a, IL-6, iNOS, CCL2, and CXCL5[1].

Western Blot Analysis[1]

Cell Line: Hepa1 cells
Concentration: 0 μM, 0.5 μM, 5 μM
Incubation Time: 12 hours
Result: Suppressed NIK-induced p52 formation in a dose-dependent manner.

RT-PCR[1]

Cell Line: Hepa1 cells
Concentration: 0 μM, 0.5 μM, 5 μM
Incubation Time: 12 hours
Result: Dose-dependently blocked NIK-induced expression of chemokines, cytokines, and iNOS in these cells. Completely blocked NIK-induced expression of TNF-a, IL-6, iNOS, CCL2, and CXCL5.
In Vivo

B022 (30 mg/kg; intravenous injection; twice a day; for 10 days; STOP-NIK male mice) treatment inhibits NIK-triggered liver inflammation and injury in STOP-NIK mice infected with cre adenoviruses[1].

Animal Model: STOP-NIK male mice (8 weeks) infected with Ad-cre[1]
Dosage: 30 mg/kg
Administration: Intravenous injection; twice a day; for 10 days
Result: Completely prevents the lethal effect of abnormally high levels of hepatic NIK in mice. Inhibited the majority of the deteriorating effects of aberrant activation of hepatic NIK.
Molecular Weight

397.88

Formula

C₁₉H₁₆ClN₅OS

CAS No.

1202764-53-1

SMILES

CC(C1=NC=CS1)(C#CC2=CC3=C(CCN3C4=NC(N)=NC=C4Cl)C=C2)O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

B022B 022B-022NF-κBNuclear factor-κBNuclear factor-kappaBInflammationNF-κB-inducingNIKTNF-aIL-6iNOSCCL2CXCL5creadenovirusesInhibitorinhibitorinhibit

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