1. GPCR/G Protein
    Immunology/Inflammation
  2. Glucocorticoid Receptor
    Interleukin Related
  3. Hydrocortisone phosphate

Hydrocortisone phosphate (Synonyms: Hydrocortisone 21-phosphate; Cortisol 21-phosphate)

Cat. No.: HY-B1155
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Hydrocortisone phosphate (Hydrocortisone 21-phosphate), a physiological glucocorticoid, and is an orally active steroidal anti-inflammatory drug (SAID). Hydrocortisone phosphate inhibits proinflammatory cytokine activity, with IC50s of 6.7 and 21.4 μM for IL-6 and IL-3, respectively. Hydrocortisone phosphate can be used for the research of ulcerative colitis (UC).

For research use only. We do not sell to patients.

Hydrocortisone phosphate Chemical Structure

Hydrocortisone phosphate Chemical Structure

CAS No. : 3863-59-0

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Description

Hydrocortisone phosphate (Hydrocortisone 21-phosphate), a physiological glucocorticoid, and is an orally active steroidal anti-inflammatory drug (SAID). Hydrocortisone phosphate inhibits proinflammatory cytokine activity, with IC50s of 6.7 and 21.4 μM for IL-6 and IL-3, respectively. Hydrocortisone phosphate can be used for the research of ulcerative colitis (UC)[1][2][3].

IC50 & Target

IL-6

6.7 μM (IC50)

IL-3

21.4 μM (IC50)

In Vitro

Hydrocortisone phosphate inhibits IL-6 and IL-3 bioactivity, with IC50s of 6.7 and 21.4 μM, respectively, and shows no cytotoxic effects on IL-6-independent MH60 cells[3].
Hydrocortisone phosphate (0.12-60 μM; 72 h) inhibits phytohemagglutinin (PHA) response in peripheral lymphocytes (PBL) and T-lymphocytes cultures[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Hydrocortisone phosphate (30 mg/kg; p.o. twice daily for 5 d) reduces the weight loss and increases the food intake in mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (200-220 g, 10-11 weeks) are induced colitis[2]
Dosage: 30 mg/kg
Administration: P.o. twice daily for 5 days
Result: Significantly decreased the disease activity index (DAI) scores and myeloperoxidase (MPO) activity compared to the 2, 4, 6-trinitrobenzenesulfonic acid (TNBS) group.
Increased the body weight.
Clinical Trial
Molecular Weight

442.44

Formula

C₂₁H₃₁O₈P

CAS No.

3863-59-0

SMILES

C[[email protected]@]12[[email protected]](C(COP(O)(O)=O)=O)(O)CC[[email protected]@]1([H])[[email protected]]3([H])CCC4=CC(CC[[email protected]]4(C)[[email protected]@]3([H])[[email protected]@H](O)C2)=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

HydrocortisoneHydrocortisone 21-phosphate Cortisol 21-phosphateGlucocorticoid ReceptorInterleukin RelatedILsteroidalanti-in?ammatorySAID,proinflammatorycytokineIL-6IL-3ulcerativecolitisUCInhibitorinhibitorinhibit

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Hydrocortisone phosphate
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