Hydrocortisone 17-valerate
Based on 1 Customer Validation
Hydrocortisone 17-valerate (Cortisol 17-valerate) is a 17α-ester derivative of Hydrocortisone (HY-N0583), an endogenous glucocorticoid with anti-inflammatory activity. Hydrocortisone 17-valerate can be used for research on skin inflammation.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 98.0%
- CAS No.: 57524-89-7
- Formule: C26H38O6
- Masse moléculaire:446.58
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vivo
Hydrocortisone 17-valerate (0.3-3 mM; topical; daily; 4 days) dose-dependently reduces mouse ear thickness, with a maximum 23.6% thinning observed at the 3 mM dose[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female weanling rats (45-50 g, n=10)[1]
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Dosage:0.03 M
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Administration:topical
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Result:Produced a 21% reduction in thymus weight compared to vehicle control.
Showed significantly lower thymus weight reduction than hydrocortisone 21-acetate (P < 0.001).
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Animal Model:Mature female white Swiss mice (n=10)[1]
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Dosage:0.3 mM; 1 mM; 3 mM
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Administration:topical; daily; 4 days
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Result:Caused a 23.6% reduction in left ear thickness at 3 mM.
Caused a 17.2% reduction in left ear thickness at 1 mM.
Caused a 14.8% reduction in left ear thickness at 0.3 mM.
Left right ear thickness unchanged, confirming no systemic effect.
Chemical Information
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CAS No. 57524-89-7
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Appearance Solid
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Masse moléculaire 446.58
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Formule C26H38O6
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Color White to off-white
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SMILES
C[C@@]12[C@](C(CO)=O)(OC(CCCC)=O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O
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Synonyms
Cortisol 17-valerate
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Pureté et documentation
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Fiche technique (273 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Hydrocortisone 17-valerate Related Classifications
HY-B1265 Related Classifications
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