1. GPCR/G Protein
    Immunology/Inflammation
  2. Glucocorticoid Receptor
    Interleukin Related
  3. Hydrocortisone hemisuccinate

Hydrocortisone hemisuccinate (Synonyms: Hydrocortisone 21-hemisuccinate)

Cat. No.: HY-B1402 Purity: 99.76%
Handling Instructions

Hydrocortisone hemisuccinate (Hydrocortisone 21-hemisuccinate), a physiological glucocorticoid, and is an orally active steroidal anti-inflammatory drug (SAID). Hydrocortisone hemisuccinate inhibits proinflammatory cytokine activity, with IC50s of 6.7 and 21.4 μM for IL-6 and IL-3, respectively. Hydrocortisone hemisuccinate can be used for the research of ulcerative colitis (UC).

For research use only. We do not sell to patients.

Hydrocortisone hemisuccinate Chemical Structure

Hydrocortisone hemisuccinate Chemical Structure

CAS No. : 2203-97-6

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Based on 1 publication(s) in Google Scholar

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Description

Hydrocortisone hemisuccinate (Hydrocortisone 21-hemisuccinate), a physiological glucocorticoid, and is an orally active steroidal anti-inflammatory drug (SAID). Hydrocortisone hemisuccinate inhibits proinflammatory cytokine activity, with IC50s of 6.7 and 21.4 μM for IL-6 and IL-3, respectively. Hydrocortisone hemisuccinate can be used for the research of ulcerative colitis (UC)[1][2][3].

IC50 & Target[1]

IL-6

6.7 μM (IC50)

IL-3

21.4 μM (IC50)

In Vitro

Hydrocortisone hemisuccinate inhibits IL-6 and IL-3 bioactivity, with IC50s of 6.7 and 21.4 μM, respectively, and shows no cytotoxic effects on IL-6-independent MH60 cells[3].
Hydrocortisone hemisuccinate (0.12-60 μM; 72 h) inhibits phytohemagglutinin (PHA) response in peripheral lymphocytes (PBL) and T-lymphocytes cultures[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Hydrocortisone hemisuccinate (30 mg/kg; p.o. twice daily for 5 d) reduces the weight loss and increases the food intake in mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (200-220 g, 10-11 weeks) are induced colitis[2]
Dosage: 30 mg/kg
Administration: P.o. twice daily for 5 days
Result: Significantly decreased the disease activity index (DAI) scores and myeloperoxidase (MPO) activity compared to the 2, 4, 6-trinitrobenzenesulfonic acid (TNBS) group.
Increased the body weight.
Clinical Trial
Molecular Weight

462.53

Formula

C₂₅H₃₄O₈

CAS No.

2203-97-6

SMILES

C[[email protected]@]12[[email protected]](C(COC(CCC(O)=O)=O)=O)(O)CC[[email protected]@]1([H])[[email protected]]3([H])CCC4=CC(CC[[email protected]]4(C)[[email protected]@]3([H])[[email protected]@H](O)C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (540.51 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1620 mL 10.8101 mL 21.6202 mL
5 mM 0.4324 mL 2.1620 mL 4.3240 mL
10 mM 0.2162 mL 1.0810 mL 2.1620 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.50 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.50 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.50 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Hydrocortisone hemisuccinateHydrocortisone 21-hemisuccinateGlucocorticoid ReceptorInterleukin RelatedILsteroidalanti-in?ammatorySAID,proinflammatorycytokineIL-6IL-3ulcerativecolitisUCInhibitorinhibitorinhibit

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Hydrocortisone hemisuccinate
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