1. Immunology/Inflammation
  2. COX
  3. COX-2-IN-10

COX-2-IN-10 

Cat. No.: HY-115976
Handling Instructions

COX-2-IN-10 is a potent COX-2 inhibitor. COX-2-IN-10 inhibits the production of PGE2 in concentration dependent manner (IC50=2.54 µM). COX-2-IN-10 inhibits the expression of iNOS and COX-2 on mRNA and protein level . COX-2-IN-10 inhibits the production of IL-6, TNF-α and IL-1β.

For research use only. We do not sell to patients.

COX-2-IN-10 Chemical Structure

COX-2-IN-10 Chemical Structure

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Description

COX-2-IN-10 is a potent COX-2 inhibitor. COX-2-IN-10 inhibits the production of PGE2 in concentration dependent manner (IC50=2.54 µM). COX-2-IN-10 inhibits the expression of iNOS and COX-2 on mRNA and protein level . COX-2-IN-10 inhibits the production of IL-6, TNF-α and IL-1β[1].

IC50 & Target[1]

COX-2

 

In Vitro

COX-2-IN-10 (compound 9k) (10 µM, 24 h) exhibits high safety and did not show any significant cytotoxicity over LPS-Induced RAW264.7 macrophage cells[1].
COX-2-IN-10 (0.4, 2, 10 µM) inhibits the production of PGE2 in concentration dependent manner in RAW264.7 macrophage cells (IC50=2.54 µM)[1].
COX-2-IN-10 (2.5, 5, 10 μM) significantly inhibits the mRNA expression of iNOS and COX-2 at 10 μM[1].
COX-2-IN-10 (2.5, 5, 10 μM) significantly inhibits iNOS and COX-2 protein level starting from 10 μM concentration[1].
COX-2-IN-10 (2.5, 5, 10 μM; 1 h) inhibits the production of IL-6, TNF-α and IL-1β[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: RAW264.7 macrophage cells
Concentration: 10 µM
Incubation Time: 24 h
Result: Exhibited high safety and did not show any significant cytotoxicity over LPS-Induced RAW264.7 macrophage cells.

RT-PCR[1]

Cell Line: RAW264.7 macrophage cells
Concentration: 2.5, 5, 10 μM
Incubation Time:
Result: Inhibits the mRNA expression of iNOS and COX-2 at 10 μM.

Western Blot Analysis[1]

Cell Line: RAW264.7 macrophage cells
Concentration: 2.5, 5, 10 μM
Incubation Time:
Result: Significantly inhibited iNOS and COX-2 protein level starting from 10 μM concentration.
Molecular Weight

557.68

Formula

C31H32FN5O2S

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
COX-2-IN-10
Cat. No.:
HY-115976
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