IL-6 aptamer sodium 

IL-6 aptamer sodium is an aptamer that specifically binds to IL-6, and can serve as a biological recognition receptor for high-sensitivity detection. IL-6 aptamer sodium enables label-free specific detection through changes in electrical signals of carbon nanotube microarrays or alterations in capacitive impedance on the surface of gold sensors. IL-6 aptamer sodium still maintains high selectivity even below the gray zone threshold for cancer diagnosis, and shows no significant non-specific binding to bovine serum albumin. IL-6 aptamer sodium can form an ordered self-assembled monolayer with 6-mercapto-1-hexanol on gold surfaces, making it suitable for reagent-free capacitive impedance biosensing platforms. IL-6 aptamer sodium is widely used in research related to fields such as cancer, inflammatory diseases, myeloma, liver cancer and glioma^[1][2][3].

The IL-6 aptamer (sodium) (1 mM MCH, 40 min)-based capacitive biosensor has reduced baseline drift (≤14% after 90 min, then leveling off) when an extra 1 mM MCH blocking step is applied, outperforming the unblocked sensor which drifts 38% over 150 min^[2].
The IL-6 aptamer (sodium) (5-10000 pg/mL IL-6, 30 min, RT, in 10% human serum)-based capacitive biosensor exhibits a dose-dependent response to IL-6 in 10% human serum, with a semi-logarithmic correlation (R=0.98) across the range of 5-10,000 pg/mL^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

9578.30

Solid

Off-white to light yellow

[IL-6 aptamer (sodium)]

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Khosravi F, et al. Ultrasensitive Label-Free Sensing of IL-6 Based on PASE Functionalized Carbon Nanotube Micro-Arrays with RNA-Aptamers as Molecular Recognition Elements. Biosensors (Basel). 2017;7(2):17. Published 2017 Apr 17.

  [2]. Sánchez-Salcedo R, et al. Comparing nanobody and aptamer-based capacitive sensing for detection of interleukin-6 (IL-6) at physiologically relevant levels. Anal Bioanal Chem. 2023;415(29-30):7035-7045.

  [3]. Gupta S, et al. Chemically modified DNA aptamers bind interleukin-6 with high affinity and inhibit signaling by blocking its interaction with interleukin-6 receptor. J Biol Chem. 2014;289(12):8706-8719.