1. Immunology/Inflammation
  2. Toll-like Receptor (TLR)
  3. MD2-TLR4-IN-1

MD2-TLR4-IN-1 

Cat. No.: HY-128598
Handling Instructions

MD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively.

For research use only. We do not sell to patients.

MD2-TLR4-IN-1 Chemical Structure

MD2-TLR4-IN-1 Chemical Structure

CAS No. : 2249801-12-3

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Description

MD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively[1].

IC50 & Target

MD2-TLR4[1].

Molecular Weight

421.28

Formula

C₂₂H₁₄Cl₂N₄O

CAS No.

2249801-12-3

SMILES

ClC1=C(C(NC2=CC(C(C3=CC=C(NC=C4)C4=C3)=NN5)=C5C=C2)=O)C(Cl)=CC=C1

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Please store the product under the recommended conditions in the Certificate of Analysis.

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MD2-TLR4-IN-1
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