2249801-12-3
2249801-12-3
Chemical Structure
MD2-TLR4-IN-1
- CAS No.: 2249801-12-3
- Formula:C22H14Cl2N4O
- Molecular Weight:421.28
IUPAC Name: N-(3-(1H-indol-5-yl)-1H-indazol-5-yl)-2,6-dichlorobenzamide
InChIKey: AZPDJGLJPDRCDQ-UHFFFAOYSA-N
SMILES: ClC1=C(C(NC2=CC(C(C3=CC=C(NC=C4)C4=C3)=NN5)=C5C=C2)=O)C(Cl)=CC=C1
Biological Activity: MD2-TLR4-IN-1 is a myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex antagonist. MD2-TLR4-IN-1 inhibits Lipopolysaccharides (HY-D1056) (LPS)-induced expression of TNF-α and IL-6 in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively. MD2-TLR4-IN-1 can be used for the study of acute lung injury (ALI)[1].
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MD2-TLR4-IN-1 | 98.16% | MD2-TLR4-IN-1 is a myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex antagonist. MD2-TLR4-IN-1 inhibits Lipopolysaccharides (HY-D1056) (LPS)-induced expression of TNF-α and IL-6 in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively. MD2-TLR4-IN-1 can be used for the study of acute lung injury (ALI). | ||||||||||||||||||||
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