1. MAPK/ERK Pathway NF-κB Stem Cell/Wnt Protein Tyrosine Kinase/RTK Metabolic Enzyme/Protease
  2. p38 MAPK NF-κB ERK JNK VEGFR MMP
  3. Emodic acid

Emodic acid (NSC624610) is an anthraquinone compound isolated from A. microcarpus, which can inhibit the proliferation of cancer cells by inhibiting the activity of NF-κB. Emodic acid can also inhibit the phosphorylation of p38, ERK and JNK, the secretion of tumor-promoting cytokines IL-1β and IL-6, and the expression of VEGF and MMP, thereby inhibiting the invasion and migration potential of cancer cells.

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Emodic acid Chemical Structure

Emodic acid Chemical Structure

CAS No. : 478-45-5

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Description

Emodic acid (NSC624610) is an anthraquinone compound isolated from A. microcarpus, which can inhibit the proliferation of cancer cells by inhibiting the activity of NF-κB. Emodic acid can also inhibit the phosphorylation of p38, ERK and JNK, the secretion of tumor-promoting cytokines IL-1β and IL-6, and the expression of VEGF and MMP, thereby inhibiting the invasion and migration potential of cancer cells[1].

In Vitro

Emodic acid(0-100 μM, 72 h) exhibits strong antiproliferative activity with the IC50 values of 9.33, 8.56, 7.95 μM in murine mammary carcinoma 4T1, MDA-231 and MCF-7 cell lines, respectively[1].
Emodic acid (50 μM, 24 h) can significantly inhibit NF-κB transcriptional activity by 80.75%, inhibit p65 phosphorylation and the mRNA expression of MMP-9 in 4T1 cell line[1].
Emodic acid(50 μM, 24 h) can inhibit the secretion of tumor-promoting cytokines IL-1β and IL-6, as well as the expression of VEGF, thereby inhibiting the invasion and migration of 4T1 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

300.22

Formula

C15H8O7

CAS No.
SMILES

OC1=CC(O)=CC(C(C2=C3C(O)=CC(C(O)=O)=C2)=O)=C1C3=O

Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Emodic acid
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