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Grossamide is a natural product that can be isolated from fructus cannabis, the dried fruit of Cannabis sativa L.. Grossamide has anti-neuroinflammatory effects.

For research use only. We do not sell to patients.

Grossamide Chemical Structure

Grossamide Chemical Structure

CAS No. : 80510-06-1

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Description

Grossamide is a natural product that can be isolated from fructus cannabis, the dried fruit of Cannabis sativa L.. Grossamide has anti-neuroinflammatory effects[1].

In Vitro

Grossamide downregulates LPS-mediated production of inflammatory molecules[1].
Grossamide (0-20 μM, 1 h) inhibits the mRNA levels of TNF-α and IL-6 in a dose-dependent manner, inhibits LPS-induced NF-κB activation, and inhibits LPS-induced TLR4 and MyD88 expression without cytotoxicity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[1]

Cell Line: BV-2 microglia cell
Concentration: 0, 10, 15, and 20 μM
Incubation Time: 1 h and co-cultured with LPS (100 ng/mL) for another 6 h
Result: Inhibited the mRNA levels of TNF-α and IL-6 in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: BV-2 microglia cell
Concentration: 0, 10, 15, and 20 μM
Incubation Time: 1 h followed by LPS (100 ng/mL) stimulation for 1 h or 24 h
Result: Inhibited LPS-induced phosphorylation of IκBα and significantly reduced phosphorylation of NF-κB p65 levels. Dose-dependently decreased the expression of TLR4 and MyD88.

Cell Viability Assay[1]

Cell Line: BV-2 microglia cell
Concentration: 0, 10, 15, and 20 μM
Incubation Time: 1 h and co-cultured in the absence or presence of 100 ng/ mL LPS for 24 h
Result: Had no cytotoxicity.
Molecular Weight

624.68

Formula

C36H36N2O8

CAS No.
SMILES

O=C([C@H]1C2=CC(/C=C/C(NCCC(C=C3)=CC=C3O)=O)=CC(OC)=C2O[C@]1([H])C(C=C4)=CC(OC)=C4O)NCCC(C=C5)=CC=C5O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Grossamide Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Grossamide
Cat. No.:
HY-N3979
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