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Cat. No.: HY-P99702

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Biologically Validated

Levilimab

Name: Levilimab
Brand: MedChemExpress
SKU: HY-P99702
Price: 240.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: BCD-089)

Customer Review

Based on 1 Customer Validation

Levilimab (BCD-089) is an IL-6 receptor blocker that binds to both membrane-bound and soluble IL-6Rα. Levilimab inhibits IL-6 signaling, including classical signaling and trans-signaling, by blocking IL-6 binding. Levilimab can be used in research on rheumatoid arthritis and COVID-19.

For research use only. We do not sell to patients.

Purity : 97.52%
CAS No.: 2035008-70-7
Molecular Weight:145.7 kDa

Storage:

Shipping with dry ice

Please store the product under the recommended conditions in the Certificate of Analysis.

Levilimab Chemical Structure

CAS No.: 2035008-70-7

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Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Application
- Verified Bioactivity
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Isotype

Human IgG1 kappa

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

^[1]^[2]^[3]

IL-6

All Interleukin Related Isoforms :

In Vitro

Cytokines and Chemokines

Levilimab binds to IL-6, thereby inhibiting IL-6 signaling^[1]^[2]^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Collagen-Induced Arthritis

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991			2011-05	PHASE1

Gene ID

3570 [NCBI]

Accession

P08887

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Human IgG1 kappa

Application

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized IL-6R alpha Protein, Human (CHO, HY-P7223) can bind Levilimab. The EC₅₀ for this effect is 24.18 ng/mL.

Chemical Information

CAS No. 2035008-70-7
Appearance Liquid
Molecular Weight 145.7 kDa
Color Colorless to light yellow
SMILES

[Levilimab]
Synonyms

BCD-089
Shipping

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

References

[1]. Rose-John S, et al. Refining therapeutic targeting of interleukin-6 by signalling mode selectivity. Nature reviews. Drug discovery. 2026 Sep 23.

[2]. Khlyabova P, et al. SAT0040 Safety, tolerability, pharmacokinetics and pharmacodynamics of bcd-089, novel monoclonal anti-il-6 receptor antibody: results from the first-in-human single dose escalation study in healthy volunteers. Ann Rheum Dis. 2018;77(Suppl 2):884-885.

[3]. Pum A, et al. Cytokines and Chemokines in SARS-CoV-2 Infections-Therapeutic Strategies Targeting Cytokine Storm. Biomolecules. 2021 Jan 12;11(1):91. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Application
- Biological Activity
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
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Quantity:

Levilimab

HOLO Human Interleukin-2 (IL-2) Detection Kit

Bradford Protein Assay Kit

Cell-ATP Viability Detection Kit

Protein A Agarose

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

PBS Buffer (1×)

All Interleukin Related Isoforms