1. Inhibitory Antibodies
  2. Omalizumab

Omalizumab (Synonyms: Olizumab; rhuMab-E25)

Cat. No.: HY-P9950

Omalizumab is a recombinant, humanized, monoclonal antibody against human immunoglobulin E (IgE) with a KD of 0.393 nM. Omalizumab binds to the human FcγRIIb receptors with a KD of 6.37 uM. Omalizumab has the potential for persistent allergic asthma research.

For research use only. We do not sell to patients.

Omalizumab Chemical Structure

Omalizumab Chemical Structure

CAS No. : 242138-07-4

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Description

Omalizumab is a recombinant, humanized, monoclonal antibody against human immunoglobulin E (IgE) with a KD of 0.393 nM. Omalizumab binds to the human FcγRIIb receptors with a KD of 6.37 uM. Omalizumab has the potential for persistent allergic asthma research[1][2].

In Vitro

Omalizumab (0.1, 0.5, 1.0, 2.0 μg/mL) has a direct effect on the B cells and can reduce the number of membrane IgE+ cells present in IL-4 plus anti-CD40 treated B cell cultures. Omalizumab alone has no effect on the viable cell number[3].
Omalizumab (1 μg/mL; 3, 7 days) reduces IL-6 secretion in human B cells. Omalizumab does not induce apoptosis in human B cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Omalizumab (10 mg/kg/day; ip; on day 8 to 42) increases IgE levels in human PBMC-engrafted severe combined immunodeficiency (huSCID) mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CAS No.
SMILES

[Olizumab]

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Keywords:

OmalizumabOlizumab rhuMab-E25OthershumanizedimmunoglobulinIgEFcγRIIballergicasthmaFcεRIIL-4CD40IL-6Inhibitorinhibitorinhibit

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