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Omalizumab  (Synonyms: Olizumab; rhuMab-E25)

Cat. No.: HY-P9950 Purity: 99.70%
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Omalizumab is a recombinant, humanized, monoclonal antibody against human immunoglobulin E (IgE) with a KD of 0.393 nM. Omalizumab binds to the human FcγRIIb receptors with a KD of 6.37 uM. Omalizumab has the potential for persistent allergic asthma research.

For research use only. We do not sell to patients.

CAS No. : 242138-07-4

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5 mg USD 620 In-stock
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Based on 1 publication(s) in Google Scholar

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1 Publications Citing Use of MCE Omalizumab

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Description

Omalizumab is a recombinant, humanized, monoclonal antibody against human immunoglobulin E (IgE) with a KD of 0.393 nM. Omalizumab binds to the human FcγRIIb receptors with a KD of 6.37 uM. Omalizumab has the potential for persistent allergic asthma research[1][2].

In Vitro

Omalizumab (0.1, 0.5, 1.0, 2.0 μg/mL) has a direct effect on the B cells and can reduce the number of membrane IgE+ cells present in IL-4 plus anti-CD40 treated B cell cultures. Omalizumab alone has no effect on the viable cell number[3].
Omalizumab (1 μg/mL; 3, 7 days) reduces IL-6 secretion in human B cells. Omalizumab does not induce apoptosis in human B cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Omalizumab (10 mg/kg/day; ip; on day 8 to 42) increases IgE levels in human PBMC-engrafted severe combined immunodeficiency (huSCID) mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

149 (kDa)

CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

[Omalizumab]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Format
  • Human IgG1 kappa
Purity & Documentation

Purity: 99.70%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Omalizumab
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