1. Immunology/Inflammation
  2. Interleukin Related
  3. SC144 hydrochloride

SC144 hydrochloride 

Cat. No.: HY-15614A Purity: 99.04%
Handling Instructions

SC144 hydrochloride is the first-in-class orally active small-molecule gp130 inhibitor; inhibits cell growth in a panel of human ovarian cancer cell lines with IC50 values in a submicromolar range.

For research use only. We do not sell to patients.

SC144 hydrochloride Chemical Structure

SC144 hydrochloride Chemical Structure

CAS No. : 917497-70-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 85 In-stock
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25 mg USD 170 In-stock
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50 mg USD 285 In-stock
Estimated Time of Arrival: December 31
100 mg USD 485 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

SC144 hydrochloride is the first-in-class orally active small-molecule gp130 inhibitor; inhibits cell growth in a panel of human ovarian cancer cell lines with IC50 values in a submicromolar range. IC50 value: < 1 uM (Cell assay) [1] Target: gp130 inhibitor SC144 shows greater potency in human ovarian cancer cell lines than in normal epithelial cells. SC144 binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes. In addition, SC144 shows potent inhibition of gp130 ligand-triggered signaling. Oral administration of SC144 delays tumor growth in a mouse xenograft model of human ovarian cancer without significant toxicity to normal tissues.

IC50 & Target[1]

IL6-beta

 

Molecular Weight

358.76

Formula

C₁₆H₁₂ClFN₆O

CAS No.

917497-70-2

SMILES

O=C(C1=NC=CN=C1)NNC2=NC3=C(N4C2=CC=C4)C=CC(F)=C3.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (27.87 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7874 mL 13.9369 mL 27.8738 mL
5 mM 0.5575 mL 2.7874 mL 5.5748 mL
10 mM 0.2787 mL 1.3937 mL 2.7874 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1 mg/mL (2.79 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.04%

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Keywords:

SC144SC 144SC-144Interleukin RelatedILInhibitorinhibitorinhibit

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Product Name:
SC144 hydrochloride
Cat. No.:
HY-15614A
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