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TAO Kinase inhibitor 1 

Cat. No.: HY-112136 Purity: 99.72%
Handling Instructions

TAO Kinase inhibitor 1 (compound 43) is a selective, ATP-competitive thousand-and-one amino acid kinases (TAOK) inhibitor with IC50s of 11 to 15 nM for TAOK1 and 2, respectively. TAO Kinase inhibitor 1 delays mitosis and induces mitotic cell death.

For research use only. We do not sell to patients.

TAO Kinase inhibitor 1 Chemical Structure

TAO Kinase inhibitor 1 Chemical Structure

CAS No. : 850467-66-2

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 76 In-stock
Estimated Time of Arrival: December 31
5 mg USD 90 In-stock
Estimated Time of Arrival: December 31
10 mg USD 160 In-stock
Estimated Time of Arrival: December 31
25 mg USD 350 In-stock
Estimated Time of Arrival: December 31
50 mg USD 650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
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500 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE TAO Kinase inhibitor 1

    TAO Kinase inhibitor 1 purchased from MCE. Usage Cited in: Eur J Pharm Sci. 2020 Sep 15;105557.

    TAO Kinase inhibitor 1 (compound 43) decreases TSN-induced YAP1 phosphorylation level in SMMC-7721 and Bel-7402 cells.
    • Biological Activity

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    Description

    TAO Kinase inhibitor 1 (compound 43) is a selective, ATP-competitive thousand-and-one amino acid kinases (TAOK) inhibitor with IC50s of 11 to 15 nM for TAOK1 and 2, respectively. TAO Kinase inhibitor 1 delays mitosis and induces mitotic cell death[1].

    In Vitro

    TAO Kinase inhibitor 1 delays mitosis and induces mitotic cell death in centrosome amplified breast cancer cells[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    384.47

    Formula

    C₂₅H₂₄N₂O₂

    CAS No.

    850467-66-2

    SMILES

    O=C(CNC(C1=CC=C(C2=CC=CC=C2)C=C1)=O)NC(CCC3)C4=C3C=CC=C4

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 62.5 mg/mL (162.56 mM; Need ultrasonic)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.6010 mL 13.0049 mL 26.0098 mL
    5 mM 0.5202 mL 2.6010 mL 5.2020 mL
    10 mM 0.2601 mL 1.3005 mL 2.6010 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.08 mg/mL (5.41 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.08 mg/mL (5.41 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    This equation is commonly abbreviated as: C1V1 = C2V2

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    × = ×
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    Keywords:

    TAO Kinase inhibitor 1TAO Kinase inhibitor1TAO Kinase inhibitor-1OthersInhibitorinhibitorinhibit

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    Product Name:
    TAO Kinase inhibitor 1
    Cat. No.:
    HY-112136
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