1. Immunology/Inflammation
  2. Interleukin Related

SC144 

Cat. No.: HY-15614 Purity: 98.05%
Handling Instructions

SC144 is the first-in-class orally active small-molecule gp130 inhibitor; inhibits cell growth in a panel of human ovarian cancer cell lines with IC50 values in a submicromolar range.

For research use only. We do not sell to patients.

SC144 Chemical Structure

SC144 Chemical Structure

CAS No. : 895158-95-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 106 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 96 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 156 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 696 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
100 mg USD 1200 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Other Forms of SC144:

  • Biological Activity

  • Protocol

  • Technical Information

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  • References

Description

SC144 is the first-in-class orally active small-molecule gp130 inhibitor; inhibits cell growth in a panel of human ovarian cancer cell lines with IC50 values in a submicromolar range. IC50 value: < 1 uM (Cell assay) [1] Target: gp130 inhibitor SC144 shows greater potency in human ovarian cancer cell lines than in normal epithelial cells. SC144 binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes. In addition, SC144 shows potent inhibition of gp130 ligand-triggered signaling. Oral administration of SC144 delays tumor growth in a mouse xenograft model of human ovarian cancer without significant toxicity to normal tissues.

Solvent & Solubility
In Vitro: 

DMSO : 19.5 mg/mL (60.50 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1027 mL 15.5135 mL 31.0270 mL
5 mM 0.6205 mL 3.1027 mL 6.2054 mL
10 mM 0.3103 mL 1.5513 mL 3.1027 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

322.3

Formula

C₁₆H₁₁FN₆O

CAS No.

895158-95-9

SMILES

O=C(C1=NC=CN=C1)NNC2=NC3=C(N4C2=CC=C4)C=CC(F)=C3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
SC144
Cat. No.:
HY-15614
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SC144

Cat. No.: HY-15614