1. Immunology/Inflammation
  2. Interleukin Related

RCGD423 

Cat. No.: HY-114775
Handling Instructions

RCGD423 is a gp130 modulator, which prevents articular cartilage degeneration and promotes repair.

For research use only. We do not sell to patients.

RCGD423 Chemical Structure

RCGD423 Chemical Structure

CAS No. : 108237-91-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2100 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

RCGD423 is a gp130 modulator, which prevents articular cartilage degeneration and promotes repair.

IC50 & Target

gp130[1]

In Vitro

RCGD423 is a gp130 modulator, which prevents articular cartilage degeneration and promotes repair[1].

In Vivo

RCGD423 greatly reduces chondrocyte hypertrophy, loss and degeneration while increasing chondrocyte proliferation beyond that observed in response to injury in a rat partial meniscectomy model. Moreover, RCGD 423 improves cartilage healing in a rat full-thickness osteochondral defect model, increasing proliferation of mesenchymal cells in the defect and also inhibiting breakdown of cartilage matrix in de novo generated cartilage[1].

Solvent & Solubility
In Vitro: 

DMSO : ≥ 160 mg/mL (483.05 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0191 mL 15.0953 mL 30.1905 mL
5 mM 0.6038 mL 3.0191 mL 6.0381 mL
10 mM 0.3019 mL 1.5095 mL 3.0191 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.67 mg/mL (8.06 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.67 mg/mL (8.06 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.67 mg/mL (8.06 mM); Suspended solution; Need ultrasonic

References
Molecular Weight

331.23

Formula

C₁₅H₁₁BrN₂S

CAS No.

108237-91-8

SMILES

BrC1=CC=C(C=C1)NC2=NC(C3=CC=CC=C3)=CS2

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
RCGD423
Cat. No.:
HY-114775
Quantity:

RCGD423

Cat. No.: HY-114775