1. Immunology/Inflammation
  2. Interleukin Related
  3. RCGD423

RCGD423 

Cat. No.: HY-114775 Purity: 99.66%
COA Handling Instructions

RCGD423 is a gp130 modulator, which prevents articular cartilage degeneration and promotes repair.

For research use only. We do not sell to patients.

RCGD423 Chemical Structure

RCGD423 Chemical Structure

CAS No. : 108237-91-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 99 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 99 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 90 In-stock
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
Estimated Time of Arrival: December 31
25 mg USD 200 In-stock
Estimated Time of Arrival: December 31
50 mg USD 290 In-stock
Estimated Time of Arrival: December 31
100 mg USD 450 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE RCGD423

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

RCGD423 is a gp130 modulator, which prevents articular cartilage degeneration and promotes repair.

IC50 & Target[1]

IL6-beta

 

In Vitro

RCGD423 is a gp130 modulator, which prevents articular cartilage degeneration and promotes repair[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

RCGD423 greatly reduces chondrocyte hypertrophy, loss and degeneration while increasing chondrocyte proliferation beyond that observed in response to injury in a rat partial meniscectomy model. Moreover, RCGD 423 improves cartilage healing in a rat full-thickness osteochondral defect model, increasing proliferation of mesenchymal cells in the defect and also inhibiting breakdown of cartilage matrix in de novo generated cartilage[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

331.23

Formula

C15H11BrN2S

CAS No.
SMILES

BrC1=CC=C(C=C1)NC2=NC(C3=CC=CC=C3)=CS2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (377.38 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0191 mL 15.0953 mL 30.1905 mL
5 mM 0.6038 mL 3.0191 mL 6.0381 mL
10 mM 0.3019 mL 1.5095 mL 3.0191 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 6.25 mg/mL (18.87 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.67 mg/mL (8.06 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.67 mg/mL (8.06 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • Dilution Calculator

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
RCGD423
Cat. No.:
HY-114775
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