108237-91-8
108237-91-8
Chemical Structure
RCGD423
- CAS No.: 108237-91-8
- Formula:C15H11BrN2S
- Molecular Weight:331.23
IUPAC Name: N-(4-bromophenyl)-4-phenylthiazol-2-amine
InChIKey: OUFYYVAASPLOAA-UHFFFAOYSA-N
SMILES: BrC1=CC=C(C=C1)NC2=NC(C3=CC=CC=C3)=CS2
Biological Activity: RCGD423 is a gp130 modulator, which prevents articular cartilage degeneration and promotes repair.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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RCGD423 | 99.92% | RCGD423 is a gp130 modulator, which prevents articular cartilage degeneration and promotes repair. | ||||||||||||||||||||
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STF-62247 | 98.69% | STF-62247 is an autophagy inducer that selectively cytotoxic to VHL-deficient renal cell carcinoma (IC50 of 0.625 μM and 16 μM in RCC4 and RCC4/VHL cells, respectively). | ||||||||||||||||||||
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GP130 receptor agonist-1 | 99.92% | GP130 receptor agonist-1 is a potent, brain-penetrant and orally active GP130 receptor agonist. GP130 receptor agonist-1 has a neuroprotective effect on NMDA-induced neurotoxicity. | ||||||||||||||||||||
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CS-1-69 | CS-1-69 is an MBD2 ligand analog that does not bind to individual NuRD components MBD2 or HDAC1, but binds robustly to the assembled NuRD complex (MBD2, HDAC1, and MT1A) in a dose-responsive manner. CS-1-69 attenuates Transcriptional Repression via Active Chemical Epigenetic Reprogrammin (TRACER)-mediated strogen receptor (ER) inhibitory activity. | |||||||||||||||||||||
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KCC-07 | 99.95% | KCC-07 is a potent and brain-penetrant MBD2 (methyl-CpG-binding domain protein 2) inhibitor. KCC-07 prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling. KCC-07 is a TRACER (transcriptional regulation via active control of epigenetic reprogramming) that can stimulate ER transcriptional activity. KCC-07 can be used for the stduy of breast cancer. | ||||||||||||||||||||
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NF-κΒ activator 1 | 99.59% | NF-κΒ activator 1 (compound 32) is a potent NF-κΒ activator with an EC50 of 0.9 μM. NF-κΒ activator 1 induces superoxide dismutase (SOD)2 mRNA expression. | ||||||||||||||||||||
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SKI II | 99.25% | SKI-II is an orally active dual-target inhibitor of SphK1/2 and DES1, with Ki values of 16 µM and 0.3 µM against SphK1 and DES1, respectively. SKI-II activates the PERK-Nrf2 antioxidant pathway by stabilizing Nrf2, and synergizes with Temozolomide (HY-17364) to induce oxidative/endoplasmic reticulum stress and cancer cell death under hypoxic conditions. In vivo, SKI-II inhibits SphK activity, promotes ceramide accumulation and apoptosis, and synergizes with Cisplatin (HY-17394) to reverse drug resistance via the ras/MAPK pathway. SKI-II reduces measles virus replication by inhibiting mTORC1 activity. SKI-II binds to VCP to induce M1 polarization, enhances host tolerance to Staphylococcus aureus infection, and exerts radioprotective effects through Nrf2 activation and accelerated DNA repair. SKI-II can be used in research related to glioblastoma, acute myeloid leukemia, gastric cancer, measles virus infection, Staphylococcus aureus infection, and acute radiation syndrome. | ||||||||||||||||||||
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Fanetizole | 98.11% | Fanetizole is an anti-inflammatory agent. Fanetizole can be used for inflammatory diseases research. | ||||||||||||||||||||
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Tyrosinase-IN-12 | 99.83% | Non-competitive tyrosinase inhibitor (Tyrosinase-IN-12) is a potent, non-competitive tyrosinase inhibitor with an IC50 value of 49.33 ± 2.64 µM and Ki value of 31.25 ± 0.25 µM. Non-competitive tyrosinase inhibitor (Tyrosinase-IN-12) have the highest radical scavenging activity to reduce the production of reactive oxygen species (ROS) with an IC50 value of 25.39 ± 0.77 µM. Non-competitive tyrosinase inhibitor (Tyrosinase-IN-12) can be used for anti-browning substances in the food and agricultural sectors. | ||||||||||||||||||||
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Antibacterial agent 143 | 91.85% | Antibacterial agent 143 (Compound 5a) is an antibacterial agent with MICs of 25, 25, 50 and 50 μg/mL against B. subtilis ATCC6633, S. aureus ATCC6538, P. aeruginosa ATCC13525 and E. coli ATCC35218, respectively. | ||||||||||||||||||||
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ARM1 | 99.60% | ARM1 (4BSA) is a potent aminopeptidase and epoxide hydrolase inhibitor. ARM1 shows aminopeptidase inhibitory activity with an IC50 7.61 µM and epoxide hydrolase inhibitory activity with an IC50 12.4 µM. | ||||||||||||||||||||
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