CS-1-69

Cat. No.: HY-128562: Data Sheet Handling Instructions
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CS-1-69 is an MBD2 ligand analog that does not bind to individual NuRD components MBD2 or HDAC1, but binds robustly to the assembled NuRD complex (MBD2, HDAC1, and MT1A) in a dose-responsive manner. CS-1-69 attenuates Transcriptional Repression via Active Chemical Epigenetic Reprogrammin (TRACER)-mediated strogen receptor (ER) inhibitory activity.

For research use only. We do not sell to patients.

CS-1-69 Chemical Structure

CAS No. : 315702-79-5

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	EC₅₀	<1.2 μM Compound: 21	Inhibition of VCP in human HeLa cells assessed as stabilization of ubiquitin-tagged luciferase after 24 hrs by reporter gene assay Inhibition of VCP in human HeLa cells assessed as stabilization of ubiquitin-tagged luciferase after 24 hrs by reporter gene assay	[PMID: 20137940]
RCC4	GI₅₀	36 μM Compound: 79	Growth inhibition of VHL-null human RCC4 cells after 4 days by XTT assay Growth inhibition of VHL-null human RCC4 cells after 4 days by XTT assay	[PMID: 19994864]

In Vitro

CS-1-69 (0-150 μM; 1 h) binds specifically to the assembled NuRD complex of purified MBD2, HDAC1, and MT1A proteins in a dose-responsive manner, with no binding to isolated MBD2 or HDAC1^[1].
CS-1-69 (25 μM; 24 h) blocks CS-1-103-mediated inhibition of ER transcriptional activity in T47D breast cancer cells, confirming CS-1-103 acts via recruitment of MBD2^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

269.32

Formula

C₁₄H₁₁N₃OS

CAS No.

315702-79-5

SMILES

OC1=CC=C(NC2=NC(C3=NC=CC=C3)=CS2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Stieger CE, et al. Targeted Transcriptional Repression by Induced Proximity. bioRxiv [Preprint]. 2025 Oct 22:2025.10.22.680877.
[Content Brief]

CS-1-69 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CS-1-69315702-79-5Estrogen Receptor/ERRHDAC1MBD2MT1AT47D breast cancer cellsTRACERERNuRD complexInhibitorinhibitorinhibit

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