Cat. No.: HY-N9965

2'-Fucosyllactose

(Synonyms: 2'-FL)

5 Cited Publications

고객리뷰

Based on 5 publication(s) in Google Scholar

2'-Fucosyllactose (2'-FL) is an oligosaccharide that could be derived from human milk. 2'-Fucosyllactose regulates the expression of CD14, alleviates colitis and regulates the gut microbiome. 2'-Fucosyllactose stimulates T cells to increase IFN-γ production and decreases IL-6, IL-17, and TNF-α production of cytokines.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 99.97%
CAS No.: 41263-94-9
화학식: C₁₈H₃₂O₁₅
분자량:488.44

보관:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

2'-Fucosyllactose Chemical Structure

CAS No.: 41263-94-9

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (5)
용액&용해도
- In Vitro
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

Target: IFN-γ, IL-6, IL-17, and TNF-α^[1]

All TNF Receptor Isoforms :

All Interleukin Related Isoforms :

In Vitro

2'-Fucosyllactose (2'-FL; 0-12 mg/mL; 48 h) suppress cell-associated CD14 expression and to attenuate LPS (100 μg/mL) stimulated IL-8 secretion in T84 cells^[1].
2'-Fucosyllactose (2 mg/mL; 48 h; T84 and HCT8 cells) ameliorates inflammation induced by bacterial invasion. 2'-Fucosyllactose inhibits ETEC invasion and attenuated the consequent IL-8 secretion^[1].
2'-Fucosyllactose (2 mg/mL; 48 h; T84 and HCT8 cells) induces macrophage migration inhibitory factor signal pathways that suppress inflammation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

T84 cells
Concentration:

0, 2, and 4 mg/mL
Incubation Time:

48 hours
Result:

Suppressed CD14 mRNA and reduced cell-associated CD14 protein expression.

Western Blot Analysis^[1]

Cell Line:

T84 and HCT8 cellsT84 and HCT8 cells
Concentration:

2 mg/mL
Incubation Time:

48 hours
Result:

Suppressed CD14 mRNA and reduced cell-associated CD14 protein expression.
Inhibited CD14 and NF-κB induction.
Induced iκB and SOCS2 expression and STAT3 phosphorylation.

In Vivo

2'-Fucosyllactose (2'-FL; 100 mg (200 μL); i.g.; daily, for 4 d; C57BL/6 mice with AIEC infection) inhibits AIEC infection and inflammation in vivo^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 mice (8 weeks) with AIEC (uropathogenic E. coli, and adherent-invasive E. coli) infection^[1]
Dosage:

100 mg (200 μL)
Administration:

Oral gavage; daily, for 4 days
Result:

Had colons lengths were closer to normal.
Inhibited the colonisation of the colonic mucosa by O83-positive bacteria.
Decreased CD14 expression, CD14 mRNA levels, IL-6, IL-17 and TNF-α levels in colonic.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 41263-94-9
Appearance Solid
분자량 488.44
화학식 C₁₈H₃₂O₁₅
Color White to off-white
SMILES

O=C[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1[C@@H]([C@H]([C@H]([C@H](O1)CO)O)O)O[C@H]2[C@H]([C@@H]([C@@H]([C@@H](O2)C)O)O)O
Synonyms

2'-FL
Structure Classification
- Saccharides
- Polysaccharides
Initial Source
- Animals
Human milk
선적

Room temperature in continental US; may vary elsewhere.
보관

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (5)

All

Sort by:

Journal Impact Factor

Food Chem

Maillard reaction with milk proteins reduced the prebiotic activity of 2'-fucosyllactose in a neonatal rat model. [Abstract]

2026 Jul 1:516:149410. PMID: 42056776
J Integr Agric

2025 Jun 2.
Tissue Cell

Oligosaccharides ameliorate insulin resistance and hepatic metabolism by promoting the leptin/POMC axis to accelerate short stature growth and development. [Abstract]

2026 Apr:99:103277. PMID: 41421172
Int Dairy J

2025 Dec 13;174:106517.
Future Sci OA

The potential of human milk oligosaccharides in ameliorating traumatic brain injury-induced cognitive impairment in mice. [Abstract]

2026 Dec;12(1):2622241. PMID: 41622772

용액&용해도

In Vitro:

H₂O : 50 mg/mL (102.37 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.0473 mL

10.2367 mL

20.4733 mL

5 mM

0.4095 mL

2.0473 mL

4.0947 mL

10 mM

0.2047 mL

1.0237 mL

2.0473 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (286 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. He Y, et, al. The human milk oligosaccharide 2'-fucosyllactose modulates CD14 expression in human enterocytes, thereby attenuating LPS-induced inflammation. Gut. 2016 Jan;65(1):33-46. [Content Brief]

[2]. Eiwegger T, et, al. Human milk--derived oligosaccharides and plant-derived oligosaccharides stimulate cytokine production of cord blood T-cells in vitro. Pediatr Res. 2004 Oct;56(4):536-40. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	2.0473 mL	10.2367 mL	20.4733 mL	51.1834 mL
	5 mM	0.4095 mL	2.0473 mL	4.0947 mL	10.2367 mL
	10 mM	0.2047 mL	1.0237 mL	2.0473 mL	5.1183 mL
	15 mM	0.1365 mL	0.6824 mL	1.3649 mL	3.4122 mL
	20 mM	0.1024 mL	0.5118 mL	1.0237 mL	2.5592 mL
	25 mM	0.0819 mL	0.4095 mL	0.8189 mL	2.0473 mL
	30 mM	0.0682 mL	0.3412 mL	0.6824 mL	1.7061 mL
	40 mM	0.0512 mL	0.2559 mL	0.5118 mL	1.2796 mL
	50 mM	0.0409 mL	0.2047 mL	0.4095 mL	1.0237 mL
	60 mM	0.0341 mL	0.1706 mL	0.3412 mL	0.8531 mL
	80 mM	0.0256 mL	0.1280 mL	0.2559 mL	0.6398 mL
	100 mM	0.0205 mL	0.1024 mL	0.2047 mL	0.5118 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

2'-Fucosyllactose

5 Cited Publications

100 mg 견적 받기

Subscribe to the

MedChemExpress

Newsletter

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

2'-Fucosyllactose

Anti-Infection Compound Library

Apoptosis Compound Library

Immunology/Inflammation Compound Library

Natural Product Library

Clinical Compound Library

Drug Repurposing Compound Library

Differentiation Inducing Compound Library

Orally Active Compound Library

Angiogenesis-Related Compound Library

Antidepressant Compound Library

Human Metabolite Library

Anti-Prostate Cancer Compound Library

Anti-Pulmonary Fibrosis Compound Library

Cancer Stem Cells Compound Library

Heterocyclic Compound Library

Pain-Related Compound Library

Mitochondrial Protection Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Autoimmune Disease Compound Library

Animal-Sourced Natural Product Library

Cytokine Inhibitors Library

Extracellular Vesicles (EVs) Compound Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Drug Repurposing Compound Library Plus

Clinical Compound Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Anti-Rheumatic Arthritis Compound Library

Mass Spectrometry Human Metabolite Library

Polysaccharides Compound Library

Natural Product Diversity Scaffold Library

Mass Spectrometry Natural Product Library

Publications Citing Use of MedChemExpress (MCE) 2'-Fucosyllactose

All TNF Receptor Isoforms

All Interleukin Related Isoforms

Biological Activity

Chemical Information

Publications (5)

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

2'-Fucosyllactose Related Classifications

HY-N9965 Related Classifications