1. Immunology/Inflammation
  2. Toll-like Receptor (TLR)
  3. Stepharine

Stepharine 

Cat. No.: HY-N9347
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Stepharine, an natural alkaloid, directly interactes with TLR4 and binds to the TLR4/MD2 complex (TLR4 inhibitor). Stepharine possesses anti-aging, anti-viral and anti-hypertensive effects.

For research use only. We do not sell to patients.

Stepharine Chemical Structure

Stepharine Chemical Structure

CAS No. : 2810-21-1

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Description

Stepharine, an natural alkaloid, directly interactes with TLR4 and binds to the TLR4/MD2 complex (TLR4 inhibitor). Stepharine possesses anti-aging, anti-viral and anti-hypertensive effects[1].

In Vitro

Stepharine (10, 30 μM) substantially inhibits nitric oxide (NO) release as well as the mRNA and protein expression of pro-inflammatory mediators [inducible nitric oxide synthase, interleukin (IL)-6, tumor necrosis factor (TNF)-α, IL-1β] in LPS-activated BV-2 cells[1].
Stepharine (10, 30 μM) inhibits LPS-induced increase of TLR4 expression, IκBα phosphorylation, and NF-κB p65 nuclear translocation[1].
Stepharine exhibits neuroprotective effects on SH-SY5Y cells cultured with LPS-treated conditioned medium. Stepharine has also shown to inhibit cholinesterase in vitro[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Stepharine (500 μg/kg) inhibited NeuN+ cells loss and Iba-1+ cells increase in the MCAO ischemic cortex[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Middle cerebral artery occlusion (MCAO) rat model[1].
Dosage: 500 μg/kg (20 μL).
Administration: Intranasally injected into rats 1h after MCAO.
Result: Attenuated the neuronal loss induced by MCAO (MCAO+ stepharine) group.
Molecular Weight

297.35

Formula

C₁₈H₁₉NO₃

CAS No.
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Please store the product under the recommended conditions in the Certificate of Analysis.

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Stepharine
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HY-N9347
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