1. Immunology/Inflammation
  2. Toll-like Receptor (TLR)
  3. ODN 21158

ODN 21158 

Cat. No.: HY-150739
Handling Instructions

ODN 21158 is a potent G-modified TLR3 andTLR9inhibitor. ODN 21158 shows no cytotoxic. ODN 21158 nhibits IFN-α secretion in a dose dependent manner.

For research use only. We do not sell to patients.

ODN 21158 Chemical Structure

ODN 21158 Chemical Structure

CAS No. : 1964506-31-7

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Description

ODN 21158 is a potent G-modified TLR3 andTLR9inhibitor. ODN 21158 shows no cytotoxic. ODN 21158 nhibits IFN-α secretion in a dose dependent manner[1].

In Vitro

ODN 21158 (0.01, 0.1, 1, 10 μM) shows no cytotoxic in human PBMCs[1].
ODN 21158 (0.01, 0.1, 1, 10 μM; 24 h) inhibits IFN-α secretion in a dose dependent manner when stimulated with CpG-ODN 2216 (3 μM) in Human PBMCs[1].
ODN 21158 (0.01, 0.1, 1, 10 μM; 48 h) stimulated with CpG-ODN 2006 (100 nM) failes to inhibit IL-6 release of PBMCs[1].
ODN 21158 (0.01, 0.1, 1, 10 μM; 48 h) inhibits the release of IL-6 when stimulated with imiquimod (5 μg/ml) in human PBMCs[1].
ODN 21158 (0.1, 1, 10 μM; 24 h) inhibits the release of IL-6 in B-cells when stimulated with imiquimod (5 μg/ml) and CpG-ODN 2006 (100 nM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: human PBMCs
Concentration: 0.01, 0.1, 1, 10 μM
Incubation Time: 48 h
Result: Did not result in increased levels of extracellular LDH and not reduced the intracellular ATP-levels of CpG-ODN 2006-stimulated PBMCs.
CAS No.
SMILES

[DNA, d(P-thio)(C-C-T-G-G-C-G-G-G-G)]

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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ODN 21158
Cat. No.:
HY-150739
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