2. Immunology/Inflammation Metabolic Enzyme/Protease
  3. Lipoxygenase COX
  4. COX-2/15-LOX-IN-2

COX-2/15-LOX-IN-2 is a potent dual COX-2 and 15-LOX inhibitor with IC50 values of 0.065 μM and 1.86 μM, respectively. COX-2/15-LOX-IN-2 has potent antioxidant activity.

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COX-2/15-LOX-IN-2

COX-2/15-LOX-IN-2 Chemical Structure

CAS No. : 3052736-49-6

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COX-2/15-LOX-IN-2 Related Antibodies

Top Publications Citing Use of Products

View All Lipoxygenase Isoform Specific Products:

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5-LOX 12-LOX 15-LOX

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COX COX-1 COX-2 COX-3

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

COX-2/15-LOX-IN-2 is a potent dual COX-2 and 15-LOX inhibitor with IC50 values of 0.065 μM and 1.86 μM, respectively. COX-2/15-LOX-IN-2 has potent antioxidant activity[1].

Cellular Effect
Cell Line Type Value Description References
RAW264.7 IC50
18.79 μM
Compound: 11
Antioxidant activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced ROS production preincubated with compound for 2 hrs followed by LPS stimulation and measured after 20 hrs by DCFH-DA probe based fluorescence analysis
Antioxidant activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced ROS production preincubated with compound for 2 hrs followed by LPS stimulation and measured after 20 hrs by DCFH-DA probe based fluorescence analysis
[PMID: 37611534]
RAW264.7 IC50
4.15 μM
Compound: 11
Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced IL-6 production preincubated for 2 hrs followed by LPS stimulation and measured after 20 hrs by ELISA
Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced IL-6 production preincubated for 2 hrs followed by LPS stimulation and measured after 20 hrs by ELISA
[PMID: 37611534]
RAW264.7 IC50
54.58 μM
Compound: 11
Antioxidant activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated with compound for 2 hrs followed by LPS stimulation and measured after 20 hrs by fluorescence microscopic analysis
Antioxidant activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated with compound for 2 hrs followed by LPS stimulation and measured after 20 hrs by fluorescence microscopic analysis
[PMID: 37611534]
RAW264.7 IC50
> 100 μM
Compound: 11
Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNF-alpha production preincubated for 2 hrs followed by LPS stimulation and measured after 20 hrs by ELISA
Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNF-alpha production preincubated for 2 hrs followed by LPS stimulation and measured after 20 hrs by ELISA
[PMID: 37611534]
Molecular Weight

514.66

Formula

C27H26N6OS2
CAS No.
SMILES

COC(C=C1)=CC=C1C2=NC3=C(C(CCCC4)=C4S3)C(NNC5=C(C(CCCC6)=C6S7)C7=NC=N5)=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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COX-2/15-LOX-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

COX-2/15-LOX-IN-23052736-49-6LipoxygenaseCOXLOXCyclooxygenaseproinflammatory cytokinesIL-6TNF-αNORAW 264.7oxidative stressInhibitorinhibitorinhibit

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