2. Immunology/Inflammation
  3. Interleukin Related
  4. Oxelumab

Oxelumab  (Synonyms: R 4930; huMAb OX 40L; Ro 49-89991)

Cat. No.: HY-P99408

Oxelumab (R 4930) is a human monoclonal antibody against the OX40 ligand (OX40L). Oxelumab can be used for the research of asthma.

For research use only. We do not sell to patients.

Oxelumab Chemical Structure

Oxelumab Chemical Structure

CAS No. : 1186098-83-8

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Description

Oxelumab (R 4930) is a human monoclonal antibody against the OX40 ligand (OX40L). Oxelumab can be used for the research of asthma[1].

In Vitro

Oxelumab (10 μg/mL; 3 d) represses cell proliferation of NK cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: Natural Killer (NK) cell lines
Concentration: 10 μg/mL
Incubation Time: 3 days
Result: Inhibited cell proliferation of NK cells.
In Vivo

Oxelumab (5 and 30 mg/kg; i.p., once daily for twice) affects the concentrations of IL-6 and the frequencies of splenic human effector memory T cells and switched B cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NSG mice with PBMCs from UC patients with simple clinical colitis activity index (SCCAI)[1]
Dosage: 5 and 30 mg/kg
Administration: Intraperitoneal injectionon; 5 and 30 mg/kg, once daily, on days 6 and 13
Result: Reversed the ethanol-induced colon dilated and the lost of distinct pattern of pellets. Decreased the level of IL-6 and increased the concentrations of glutamic acid. Reduced frequencies of splenic human effector memory T cells and switched B cells.
CAS No.
SMILES

[Oxelumab]
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Oxelumab1186098-83-8R 4930 huMAb OX 40L Ro 49-89991R4930R-4930Interleukin RelatedILAsthmaNKIL-6T cellB cellmiceInhibitorinhibitorinhibit

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