2. Anti-infection
  3. SARS-CoV
  4. SIMR3030

SIMR3030 is a potent SARS-CoV-2 PLpro inhibitor with an IC50 value of 0.0399 µg/mL. SIMR3030 shows antiviral activity. SIMR3030 decreases SARS-CoV spike, ORF1b, IFN-α, IL-6 mRNA expression. SIMR3030 exhibits a satisfactory safety profile in mice.

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SIMR3030

SIMR3030 Chemical Structure

CAS No. : 2708270-99-7

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SIMR3030 Related Antibodies

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Description

SIMR3030 is a potent SARS-CoV-2 PLpro inhibitor with an IC50 value of 0.0399 µg/mL. SIMR3030 shows antiviral activity. SIMR3030 decreases SARS-CoV spike, ORF1b, IFN-α, IL-6 mRNA expression. SIMR3030 exhibits a satisfactory safety profile in mice[1].

IC50 & Target

IC50: 0.0399 µg/mL (SARS-CoV-2 PLpro)[1]
Cellular Effect
Cell Line Type Value Description References
Vero C1008 CC50
55.63 μg/mL
Compound: SIMR3030
Cytotoxicity against African green monkey Vero E6 cells measured after 72 hrs by crystal violet staining based analysis
Cytotoxicity against African green monkey Vero E6 cells measured after 72 hrs by crystal violet staining based analysis
[PMID: 37075625]
In Vitro

SIMR3030 (0-100 µg/mL) shows antiviral activity with IC50 values of 12.1, 6.206 μg/mL for SARS-CoV-2 and MERS-CoV, respectively[1].
SIMR3030 (20 µg/mL; 1, 6, 12 h) decreases SARS-CoV spike, ORF1b, IFN-α, IL-6 mRNA expression levels in Caco-2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SIMR3030 Related Antibodies

RT-PCR[1]

Cell Line: Caco-2 cells (SARS-CoV-2 RNA infected)
Concentration: 20 μg/mL
Incubation Time: 1, 6, 12 h
Result: Decreased SARS-CoV spike and ORF1b mRNA expression levels, reduced the mRNA expression of IFN-α at 1 and 3 h , IL-6 and OAS1 at 1, 3 and 12 h.
In Vivo

SIMR3030 (25, 50, 100 mg/kg; I.p.; daily for 14 days) exhibits a satisfactory safety profile in experimental mice model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 18-25 g, adult female Balb/c mice[1]
Dosage: 25, 50, 100 mg/kg
Administration: I.p.; daily for 14 days
Result: Showed no signs of toxicity or weight loss were noticed during 12.5 and 25 mg/kg multiple-dose studies for 14 days, no signs of toxicity or weight loss were noticed during 12.5 and 25 mg/kg multiple-dose studies for 14 days.
Molecular Weight

427.54

Formula

C27H29N3O2
CAS No.
SMILES

[H][C@@]12CC[C@]3(CC4=C(NC5=C4C=C(C=C5)OC)C[C@]3(N1CCC6=C2NC7=CC=CC=C76)[H])OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SIMR3030 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SIMR30302708270-99-7SIMR 3030SIMR-3030SARS-CoVSARS coronavirusCaco-2 cellsantiviralSARS-CoV spikeORF1bIFN-αIL-6Inhibitorinhibitorinhibit

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