2. Anti-infection
  3. SARS-CoV
  4. SIMR3030

SIMR3030 is a potent SARS-CoV-2 PLpro inhibitor with an IC50 value of 0.0399 µg/mL. SIMR3030 shows antiviral activity. SIMR3030 decreases SARS-CoV spike, ORF1b, IFN-α, IL-6 mRNA expression. SIMR3030 exhibits a satisfactory safety profile in mice.

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SIMR3030 Chemical Structure

SIMR3030 Chemical Structure

CAS No. : 2708270-99-7

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SIMR3030 Related Antibodies

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Description

SIMR3030 is a potent SARS-CoV-2 PLpro inhibitor with an IC50 value of 0.0399 µg/mL. SIMR3030 shows antiviral activity. SIMR3030 decreases SARS-CoV spike, ORF1b, IFN-α, IL-6 mRNA expression. SIMR3030 exhibits a satisfactory safety profile in mice[1].

IC50 & Target

IC50: 0.0399 µg/mL (SARS-CoV-2 PLpro)[1]
In Vitro

SIMR3030 (0-100 µg/mL) shows antiviral activity with IC50 values of 12.1, 6.206 μg/mL for SARS-CoV-2 and MERS-CoV, respectively[1].
SIMR3030 (20 µg/mL; 1, 6, 12 h) decreases SARS-CoV spike, ORF1b, IFN-α, IL-6 mRNA expression levels in Caco-2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SIMR3030 Related Antibodies

RT-PCR[1]

Cell Line: Caco-2 cells (SARS-CoV-2 RNA infected)
Concentration: 20 μg/mL
Incubation Time: 1, 6, 12 h
Result: Decreased SARS-CoV spike and ORF1b mRNA expression levels, reduced the mRNA expression of IFN-α at 1 and 3 h , IL-6 and OAS1 at 1, 3 and 12 h.
In Vivo

SIMR3030 (25, 50, 100 mg/kg; I.p.; daily for 14 days) exhibits a satisfactory safety profile in experimental mice model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 18-25 g, adult female Balb/c mice[1]
Dosage: 25, 50, 100 mg/kg
Administration: I.p.; daily for 14 days
Result: Showed no signs of toxicity or weight loss were noticed during 12.5 and 25 mg/kg multiple-dose studies for 14 days, no signs of toxicity or weight loss were noticed during 12.5 and 25 mg/kg multiple-dose studies for 14 days.
Molecular Weight

427.54

Formula

C27H29N3O2
CAS No.
SMILES

[H][C@@]12CC[C@]3(CC4=C(NC5=C4C=C(C=C5)OC)C[C@]3(N1CCC6=C2NC7=CC=CC=C76)[H])OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SIMR3030 Related Classifications

  • Molarity Calculator

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SIMR30302708270-99-7SIMR 3030SIMR-3030SARS-CoVSARS coronavirusCaco-2 cellsantiviralSARS-CoV spikeORF1bIFN-αIL-6Inhibitorinhibitorinhibit

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