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  3. Bazedoxifene-d4

Bazedoxifene-d4 (Synonyms: TSE-424-d4)

Cat. No.: HY-A0031S
Handling Instructions

Bazedoxifene-d4 is deuterium labeled Bazedoxifene. Bazedoxifene (TSE-424) is an oral, BBB-penetrant nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively. Bazedoxifene can be used for the research of osteoporosis. Bazedoxifene also acts as an inhibitor of IL-6/GP130 protein-protein interactions and can be used for the research of pancreatic cancer.

For research use only. We do not sell to patients.

Bazedoxifene-d4 Chemical Structure

Bazedoxifene-d4 Chemical Structure

CAS No. : 1133695-49-4

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Description

Bazedoxifene-d4 is deuterium labeled Bazedoxifene. Bazedoxifene (TSE-424) is an oral, BBB-penetrant nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively. Bazedoxifene can be used for the research of osteoporosis. Bazedoxifene also acts as an inhibitor of IL-6/GP130 protein-protein interactions and can be used for the research of pancreatic cancer[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

474.63

Formula

C30H30D4N2O3

CAS No.
SMILES

CC1=C(N(C2=C1C=C(C=C2)O)CC3=CC=C(C=C3)OC([2H])(C([2H])(N4CCCCCC4)[2H])[2H])C5=CC=C(C=C5)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Bazedoxifene-d4
Cat. No.:
HY-A0031S
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