1. Anti-infection
  2. Parasite
  3. DHQZ 36

DHQZ 36 

Cat. No.: HY-123601
Handling Instructions

DHQZ 36 is a potent inhibitor of retrograde trafficking. DHQZ 36 inhibits Leishmania amazonensis infection in macrophages with an EC50 of 13.63 μM. DHQZ 36 has potent anti-parasite activity.

For research use only. We do not sell to patients.

DHQZ 36 Chemical Structure

DHQZ 36 Chemical Structure

CAS No. : 1542098-94-1

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Description

DHQZ 36 is a potent inhibitor of retrograde trafficking. DHQZ 36 inhibits Leishmania amazonensis infection in macrophages with an EC50 of 13.63 μM. DHQZ 36 has potent anti-parasite activity[1].

IC50 & Target

EC50: 13.63 μM (Leishmania amazonensis)[1]

In Vitro

With increasing concentrations of DHQZ 36 there is a significant diminution in the size of parasitophorous vacuoles (LPVs), vacuole sizes are reduced by 30% at 50 μM. These parasites also cause a reduction in the number of parasites per macrophage. Significant parasite loss is observed with as low as 5 μM after treatment with DHQZ 36. Parasites are unable to recover growth when treated with DHQZ 36 at concentrations at or above 12.5 μM[1].
DHQZ 36 causes over 40% reduction in secreted of parasite proteins. DHQZ 36 causes a reversal in Leishmania induced suppression of IL-6 release by infected cells after LPS activation[1].

Molecular Weight

384.44

Formula

C₂₁H₁₈F₂N₂OS

CAS No.

1542098-94-1

SMILES

O=C1N(CC2=CC=C(F)C=C2)C(C3=CC=C(CC)S3)NC4=C1C=C(F)C=C4

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

DHQZ 36DHQZ36DHQZ-36ParasiteLeishmaniaamazonensisparasitophorousvacuolesIL-6LPSanti-parasite InfectionInhibitorinhibitorinhibit

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DHQZ 36
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