1. Immunology/Inflammation
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. Interleukin Related
    STAT
  3. Balsalazide

Balsalazide 

Cat. No.: HY-B0667 Purity: 99.20%
Handling Instructions

Balsalazide could suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.

For research use only. We do not sell to patients.

Balsalazide Chemical Structure

Balsalazide Chemical Structure

CAS No. : 80573-04-2

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Solution
10 mM * 1 mL in DMSO USD 131 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 131 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 119 In-stock
Estimated Time of Arrival: December 31
50 mg USD 432 In-stock
Estimated Time of Arrival: December 31
100 mg USD 672 In-stock
Estimated Time of Arrival: December 31
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Description

Balsalazide could suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.

IC50 & Target[1][2]

IL-6

 

STAT3

 

In Vivo

At the endpoint, the protein production of MIP-1β, MCP-1, IL-6, and IL-10 in the colon tissues decrease in concordance with the plasma concentrations of the cytokines. The drug-treated groups reveal lower expression of p-STAT3 compared to the CAC group. In addition, BCL2 decreases and BAX increases markedly in the BSZ+VSL#3 group[1]. Balsalazide is a new 5-aminosalicylic acid (5-ASA) containing prodrug[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

357.32

Formula

C₁₇H₁₅N₃O₆

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (279.86 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7986 mL 13.9931 mL 27.9861 mL
5 mM 0.5597 mL 2.7986 mL 5.5972 mL
10 mM 0.2799 mL 1.3993 mL 2.7986 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.00 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.00 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Animal Administration
[1]

Mice[1]
C57B/L6J mice are randomly divided into four groups: CAC group, Balsalazide (BSZ) group (300 mg/kg), VSL#3 group, and BSZ+VSL#3 group. After two weeks, the AOM/DSS model is induced by AOM injection followed by two cycles of 2% DSS[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: 99.20%

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Balsalazide
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HY-B0667
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