1. JAK/STAT Signaling Stem Cell/Wnt
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  3. Corylifol A

Corylifol A  (Synonyms: Corylifol-A; Corylinin)

Cat. No.: HY-N0897 Purity: 99.58%
COA Handling Instructions

Corylifol A inhibits IL-6-induced STAT3 activation and phosphorylation, with an IC50 of 0.81 μM.

For research use only. We do not sell to patients.

Corylifol A Chemical Structure

Corylifol A Chemical Structure

CAS No. : 775351-88-7

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 181 In-stock
Solution
10 mM * 1 mL in DMSO USD 181 In-stock
Solid
1 mg USD 60 In-stock
5 mg USD 120 In-stock
10 mg USD 190 In-stock
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Based on 2 publication(s) in Google Scholar

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Description

Corylifol A inhibits IL-6-induced STAT3 activation and phosphorylation, with an IC50 of 0.81 μM.

IC50 & Target

STAT3

0.81 μM (IC50)

In Vitro

Corylifol A shows an inhibitory effect on IL-6-induced STAT3 promoter activity in Hep3B cells with IC50 value of 0.81±0.15 μM, also inhibits STAT3 phosphorylation induced by IL-6 in Hep3B cells[1]. Corylifol A inhibits SARA PLpro in a dose-dependent manner with IC50s ranging between 4.2 and 38.4 μM[2]. Corylifol A is found to be a naturally occurring potent inhibitor of hCE2, with low Ki values ranging from 0.62 μM to 3.89 μM[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

390.47

Formula

C25H26O4

CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C1C(C2=CC=C(O)C(C/C=C(C)/CC/C=C(C)\C)=C2)=COC3=CC(O)=CC=C13

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (640.25 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5610 mL 12.8051 mL 25.6102 mL
5 mM 0.5122 mL 2.5610 mL 5.1220 mL
10 mM 0.2561 mL 1.2805 mL 2.5610 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (5.33 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (5.33 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.08 mg/mL (5.33 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.90%

References
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Corylifol A Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
Corylifol A
Cat. No.:
HY-N0897
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