1. JAK/STAT Signaling
    Stem Cell/Wnt
  2. STAT
  3. Corylifol A

Corylifol A (Synonyms: Corylifol-A; Corylinin)

Cat. No.: HY-N0897 Purity: 99.75%
Handling Instructions

Corylifol A inhibits IL-6-induced STAT3 activation and phosphorylation, with an IC50 of 0.81 μM.

For research use only. We do not sell to patients.

Corylifol A Chemical Structure

Corylifol A Chemical Structure

CAS No. : 775351-88-7

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5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 250 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Corylifol A inhibits IL-6-induced STAT3 activation and phosphorylation, with an IC50 of 0.81 μM.

IC50 & Target

STAT3

0.81 μM (IC50)

In Vitro

Corylifol A shows an inhibitory effect on IL-6-induced STAT3 promoter activity in Hep3B cells with IC50 value of 0.81±0.15 μM, also inhibits STAT3 phosphorylation induced by IL-6 in Hep3B cells[1]. Corylifol A inhibits SARA PLpro in a dose-dependent manner with IC50s ranging between 4.2 and 38.4 μM[2]. Corylifol A is found to be a naturally occurring potent inhibitor of hCE2, with low Ki values ranging from 0.62 μM to 3.89 μM[3].

Molecular Weight

390.47

Formula

C₂₅H₂₆O₄

CAS No.

775351-88-7

SMILES

O=C1C(C2=CC=C(O)C(C/C=C(C)/CC/C=C(C)\C)=C2)=COC3=CC(O)=CC=C13

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 15.4 mg/mL (39.44 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5610 mL 12.8051 mL 25.6102 mL
5 mM 0.5122 mL 2.5610 mL 5.1220 mL
10 mM 0.2561 mL 1.2805 mL 2.5610 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.75%

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Keywords:

Corylifol ACorylifol-ACorylininSTATInhibitorinhibitorinhibit

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Corylifol A
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