Fasitibant chloride hydrochloride
Based on 1 publication(s) in Google Scholar
Fasitibant chloride hydrochloride (MEN16132) is a potent, selective, high affinity, and long-lasting nonpeptide bradykinin B2 (BK2) receptor antagonist. Fasitibant chloride hydrochloride has proinflammatory effects and can be used for the research of osteoarthritis and rheumatoid arthritis.
For research use only. We do not sell to patients.
- CAS No.: 869880-33-1
- Formula: C36H50Cl4N6O6S
- Molecular Weight:836.70
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Fasitibant chloride hydrochloride
MoreAll Bradykinin Receptor Isoforms
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Biological Activity
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Bradykinin B2 Receptor (B2R) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male wistar rats with inflammatory arthritis[2]
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Dosage:100 µg per knee
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Administration:Injection into the knee joint; 100 µg per knee; combines with dexamethasone
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Result:Was more effective than each drug administered alone in inhibiting knee joint inflammation. Reduced joint pain and diminished joint oedema.
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Animal Model:Male Wistar rats with inflammatory arthritis[2]
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Dosage:100 µg per knee
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Administration:Injection into the knee joint; 100 µg per knee; combines with dexamethasone
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Result:Was more effective than each drug administered alone in inhibiting knee joint inflammation. Reduced joint pain and diminished joint oedema.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 869880-33-1
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Molecular Weight 836.70
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Formula C36H50Cl4N6O6S
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SMILES
O=C(N(CC1)CCN1C([C@@H](N)CCC[N+](C)(C)C)=O)C2(CCOCC2)N[S](=O)(C(C=CC(Cl)=C3COC4=CC=CC(C(C)=C5)=C4N=C5C)=C3Cl)=O.[Cl-].Cl
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Synonyms
MEN16132
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Nat Commun
Endothelial Sp1/Sp3 are essential to the effect of captopril on blood pressure in male mice. [Abstract]2023 Sep 21;14(1):5891. PMID: 37735515
Purity & Documentation
References
[1]. S Meini, et al. Fasitibant prevents the bradykinin and interleukin 1β synergism on prostaglandin E₂ release and cyclooxygenase 2 expression in human fibroblast-like synoviocytes. Naunyn Schmiedebergs Arch Pharmacol. 2012 Aug;385(8):777-86. [Content Brief]
[2]. Claudio Valenti, et al. Fasitibant chloride, a kinin B₂ receptor antagonist, and dexamethasone interact to inhibit carrageenan-induced inflammatory arthritis in rats. Br J Pharmacol. 2012 Jun;166(4):1403-10. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Fasitibant chloride hydrochloride Related Classifications
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