MEN 11270
Based on 1 Customer Validation
MEN 11270, a cyclic decapeptide, is a B2 kinin receptor antagonist. MEN 11270 bound with high-affinity to the B2 kinin receptor constitutively expressed by WI38 human fibroblasts, inhibiting 3H-bradykinin (BK) with a pKi value of 10.3.
For research use only. We do not sell to patients.
- Purity: 99.15%
- CAS No.: 235082-52-7
- Formula: C60H90N20O11S
- Molecular Weight:1299.55
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Storage:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-17446
Icatibant
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HY-15043
ELN-441958
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![Sar-[D-Phe8]-des-Arg9-Bradykinin](https://file.medchemexpress.com/product_pic/hy-103291.gif)
HY-103291
Sar-[D-Phe8]-des-Arg9-Bradykinin
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HY-103290
R715
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HY-P0206
Bradykinin
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HY-108896
Icatibant acetate
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HY-15039
SSR240612
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HY-17446R
Icatibant (Standard)
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HY-103293
Lys-Bradykinin
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![Lys-[Des-Arg9]Bradykinin](https://file.medchemexpress.com/product_pic/hy-103295.gif)
HY-103295
Lys-[Des-Arg9]Bradykinin
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![[Phe8Ψ(CH-NH)Arg9]-Bradykinin](https://file.medchemexpress.com/product_pic/hy-103292.gif)
HY-103292
[Phe8Ψ(CH-NH)Arg9]-Bradykinin
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HY-105155
Lobradimil
All Bradykinin Receptor Isoforms
More
Biological Activity
Chemical Information
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CAS No. 235082-52-7
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Appearance Solid
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Molecular Weight 1299.55
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Formula C60H90N20O11S
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Color White to off-white
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Sequence
{d-Arg}-Arg-Pro-{Hyp}-Gly-{Thi}-c({Dab}-{d-Tic}-{Oic}-Arg)c(7γ-10α)
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Sequence Shortening
{d-Arg}-RP-{Hyp}-G-{Thi}-c({Dab}-{d-Tic}-{Oic}-R)c(7γ-10α)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 100 mg/mL (76.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (1.92 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.7695 mL | 3.8475 mL | 7.6950 mL | 19.2374 mL |
| 5 mM | 0.1539 mL | 0.7695 mL | 1.5390 mL | 3.8475 mL | |
| 10 mM | 0.0769 mL | 0.3847 mL | 0.7695 mL | 1.9237 mL | |
| 15 mM | 0.0513 mL | 0.2565 mL | 0.5130 mL | 1.2825 mL | |
| 20 mM | 0.0385 mL | 0.1924 mL | 0.3847 mL | 0.9619 mL | |
| 25 mM | 0.0308 mL | 0.1539 mL | 0.3078 mL | 0.7695 mL | |
| 30 mM | 0.0256 mL | 0.1282 mL | 0.2565 mL | 0.6412 mL | |
| 40 mM | 0.0192 mL | 0.0962 mL | 0.1924 mL | 0.4809 mL | |
| 50 mM | 0.0154 mL | 0.0769 mL | 0.1539 mL | 0.3847 mL | |
| 60 mM | 0.0128 mL | 0.0641 mL | 0.1282 mL | 0.3206 mL |
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