235082-52-7
Chemical Structure
MEN 11270
- CAS No.: 235082-52-7
- Formula:C60H90N20O11S
- Molecular Weight:1299.55
IUPAC Name: (2S,4R)-1-(D-arginyl-L-arginyl-L-prolyl)-N-(2-(((S)-1-(((8S,13S,15aS,16aS,20aS,22aR)-13-(3-guanidinopropyl)-7,12,15,22-tetraoxo-5,8,9,10,11,12,13,14,15,15a,16,16a,17,18,19,20,20a,22,22a,23-icosahydro-7H-indolo[1',2':4,5][1,4,7,10]tetraazacyclotetradecino[
InChIKey: LPLBKEKLEUYDEJ-CQSFJRBESA-N
SMILES: O=C([C@]1([H])N(C([C@H]2NC([C@@H](NC(CNC([C@H](C[C@H]3O)N(C3)C([C@H](CCC4)N4C([C@H](CCCNC(N)=N)NC([C@H](N)CCCNC(N)=N)=O)=O)=O)=O)=O)CC5=CC=CS5)=O)=O)CC6=CC=CC=C6C1)N7[C@](CCCC8)([H])[C@]8([H])C[C@@]7([H])C(N[C@H](C(NCC2)=O)CCCNC(N)=N)=O
Biological Activity: MEN 11270, a cyclic decapeptide, is a B2 kinin receptor antagonist. MEN 11270 bound with high-affinity to the B2 kinin receptor constitutively expressed by WI38 human fibroblasts, inhibiting 3H-bradykinin (BK) with a pKi value of 10.3[1].
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MEN 11270 | 99.15% | MEN 11270, a cyclic decapeptide, is a B2 kinin receptor antagonist. MEN 11270 bound with high-affinity to the B2 kinin receptor constitutively expressed by WI38 human fibroblasts, inhibiting 3H-bradykinin (BK) with a pKi value of 10.3. | ||||||||||||||||||||
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Keywords
