1. Apoptosis
  2. Caspase
  3. Z-Asp-CH2-DCB

Z-Asp-CH2-DCB 

Cat. No.: HY-113953 Purity: >99.0%
Handling Instructions

Z-Asp-CH2-DCB is an irreversible broad spectrum caspase inhibitor. Z-Asp-CH2-DCB also inhibits proteases with caspase-like activity. Z-D-CH2-DCB blocks the production of IL-1β, TNF-α, IL-6, and IFN-γ in staphylococcal enterotoxin B (SEB)-stimulated peripheral blood mononuclear cells (PBMC), and reduces SEB-1-stimulated T-cell proliferation in a dose-dependent manner. Z-Asp-CH2-DCB prevents SU5416-induced septal cell apoptosis and emphysema development.

For research use only. We do not sell to patients.

Z-Asp-CH2-DCB Chemical Structure

Z-Asp-CH2-DCB Chemical Structure

CAS No. : 153088-73-4

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10 mM * 1 mL in DMSO USD 188 In-stock
Estimated Time of Arrival: December 31
1 mg USD 65 In-stock
Estimated Time of Arrival: December 31
5 mg USD 188 In-stock
Estimated Time of Arrival: December 31
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Description

Z-Asp-CH2-DCB is an irreversible broad spectrum caspase inhibitor. Z-Asp-CH2-DCB also inhibits proteases with caspase-like activity. Z-D-CH2-DCB blocks the production of IL-1β, TNF-α, IL-6, and IFN-γ in staphylococcal enterotoxin B (SEB)-stimulated peripheral blood mononuclear cells (PBMC), and reduces SEB-1-stimulated T-cell proliferation in a dose-dependent manner. Z-Asp-CH2-DCB prevents SU5416-induced septal cell apoptosis and emphysema development[1][2][3].

In Vitro

Z-Asp-CH2-DCB (10-100 μM) blocks the production of IL-1β, TNF-α, IL-6, and IFN-γ in SEB-stimulated (200 ng; 16 hours) PBMC in a dose-dependent manner. The production of the chemokines MCP-1, MIP-1α, and MIP-1β was also suppresses. The inhibitory effect of Z-Asp-CH2-DCB on TSST-1-activated PBMC is similar, reducing IL-1β, IL-6, TNF-α, IFN-γ, MCP-1, MIP-1α, and MIP-1β to 10, 36, 25, 10, 11, 25, and 30%, respectively, of levels in untreated cells[1].
Z-Asp-CH2-DCB (10-100 μM; 48 hours) inhibits T-cell proliferation in PBMC stimulated with 200 ng of SEB/ml [1].

Cell Viability Assay[1]

Cell Line: Human peripheral blood mononuclear cells
Concentration: 10, 50, 100 μM
Incubation Time: 48 hours
Result: Inhibited T-cell proliferation in PBMC stimulated with SEB.
In Vivo

Z-Asp-CH2-DCB (1 mg; i.p.; every day for 3 weeks) prevents SU5416-induced septal cell apoptosis[1].

Animal Model: Male Sprague-Dawley rats (SU5416+ Z-Asp-CH2-DCB group)[1]
Dosage: 1 mg
Administration: Intraperitoneal injection; every day for 3 weeks
Result: The caspase 3-like activity in SU5416-treated rat lungs is significantly higher, whereas lungs from rats treated with SU5416+Z-Asp-CH2-DCB showed no increase in apoptotic activity.
Molecular Weight

454.26

Formula

C₂₀H₁₇Cl₂NO₇

CAS No.

153088-73-4

SMILES

O=C(OCC([[email protected]@H](NC(OCC1=CC=CC=C1)=O)CC(O)=O)=O)C2=C(Cl)C=CC=C2Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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Keywords:

Z-Asp-CH2-DCBCaspasepanproteasescaspase-likeproinflammatorycytokineschemokinesPBMCapoptosisT-cellproliferationInhibitorinhibitorinhibit

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Z-Asp-CH2-DCB
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