132197-26-3
Chemical Structure
MCI-727 free base
- CAS No.: 132197-26-3
- Formula:C21H27N3O
- Molecular Weight:337.46
IUPAC Name: (Z)-2-(4-methylpiperazin-1-yl)-1-(4-phenethylphenyl)ethan-1-one oxime
InChIKey: RKIPRMWYKDVBLY-QURGRASLSA-N
SMILES: CN1CCN(C/C(C2=CC=C(CCC3=CC=CC=C3)C=C2)=N\O)CC1
Biological Activity: MCI-727 free base is an orally active anti-ulcer agent. MCI-727 free base can increase the plasma secretin concentration in rats and dogs. MCI-727 free base can also stimulate the exocrine function of the pancreas in rats by promoting the release of endogenous secretin, and exert preventive and therapeutic effects on mild acute pancreatitis. MCI-727 free base can be used in the research of ulcer-related diseases[1][2].
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MCI-727 free base | MCI-727 free base is an orally active anti-ulcer agent. MCI-727 free base can increase the plasma secretin concentration in rats and dogs. MCI-727 free base can also stimulate the exocrine function of the pancreas in rats by promoting the release of endogenous secretin, and exert preventive and therapeutic effects on mild acute pancreatitis. MCI-727 free base can be used in the research of ulcer-related diseases. | |||||||||||||||||||||
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- [1]. Kawamura M, et al. Effects of MCI-727, a new anti-ulcer agent, on plasma secretin concentration in rats and dogs and pancreatic exocrine secretion in rats. Jpn J Pharmacol. 1991 Aug;56(4):513-22. [Content Brief]
- [2]. Tachibana I, et al. Effects of MCI-727 on pancreatic exocrine secretion and acute pancreatitis in two experimental rat models. Pancreas. 1996 Mar;12(2):165-72. [Content Brief]
Keywords
