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  2. Peptide C105Y TFA

Peptide C105Y TFA 

Cat. No.: HY-P1781A
Handling Instructions

Peptide C105Y TFA, a synthetic and cell-penetrating peptide based on the amino acid sequence corresponding to residues 359-374 of α1-antitrypsin, enhances gene expression from DNA nanoparticles.

For research use only. We do not sell to patients.

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Peptide C105Y TFA Chemical Structure

Peptide C105Y TFA Chemical Structure

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Description

Peptide C105Y TFA, a synthetic and cell-penetrating peptide based on the amino acid sequence corresponding to residues 359-374 of α1-antitrypsin, enhances gene expression from DNA nanoparticles[1].

In Vitro

When human hepatoma cells (HuH7) were incubated with fluorescently labeled C105Y for as little as 3 min, C105Y displays nuclear and cytoplasmic staining with enrichment of fluorescent signal in the nucleus and nucleolus. C105Y peptide is routed to the nucleolus very rapidly in an energy-dependent fashion, whereas membrane translocation and nuclear localization are energy-independent. When tested the involvement of known endocytosis pathways in uptake and trafficking of this peptide, C105Y peptide is internalized by a clathrin- and caveolin-independent pathway, although lipid raft-mediated endocytosis may play a role in peptide intracellular trafficking[1].

Molecular Weight

2108.42

Formula

C₉₉H₁₄₉F₃N₂₀O₂₅S

Sequence Shortening

CSIPPEVKFNKPFVYLI

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Peptide C105YOtherscell-penetratingα1-antitrypsingeneexpressionnanoparticlesDNAInhibitorinhibitorinhibit

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Peptide C105Y TFA
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HY-P1781A
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