Secretin (swine)
Based on 1 Customer Validation
Secretin (swine), a neuroendocrine hormone, is the first hormone to be identifie and is secreted by S cells that are localized primarily in the mucosa of the duodenum. Secretin also is a 27-amino acid peptide, which acts on secretin receptors. Secretin is expressed by cells in all mature enteroendocrine cell subsets and can be prompted by fatty acids. Secretin stimulates the secretion of pancreatic water and bicarbonate. Secretin exerts various effects in organs, can be used for the research of digestive system, central nervous system and energy metabolism.
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- Pureté: 98.88%
- CAS No.: 17034-35-4
- Formule: C130H220N44O41
- Masse moléculaire:3055.41
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Stockage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Secretin (swine) (10-7M, 10-6M; 24 to 72 h and 7 days) stimulates biliary growth by interaction with secretin receptors (SR) and knockout of SR reduces biliary proliferation by downregulating cAMP dependent signaling[2].
Secretin (10-7M, 10-6M; 24 to 72 h and 7 days) increases the proliferation in human HIBEpiC and large murine cholangiocyte lines[2][3][4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:large murine cholangiocyte lines
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Concentration:10−7M, 10−6 M
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Incubation Time:24 to 72 h and 7 days
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Result:Increased the proliferation of cholangiocytes.
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Cell Line:human HIBEpiC and large murine cholangiocyte lines
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Concentration:10−7M, 10−6M
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Incubation Time:24 to 72 h and 7 days
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Result:Increased the proliferation of non-transfected, vector-transfected and secretin shRNA large cholangiocytes and HiBEpiC compared to the cell lines treated with BSA (basal).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sct+/- mice[2]
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Dosage:2.5 nM/kg
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Administration:2.5 nM/kg, BW/day, osmotic minipumps, for 1 week
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Result:Increased in supernatants from cholangiocytes and S cells and in serum and bile following BDL in control mice.
Had low IBDM, reduced proliferation, and reduced production of vascular endothelial growth factor A (VEGFA) and nerve growth factor (NGF) in BDL Sct+/- mice.
Regulated VEGF and NGF expression that negatively correlated with microRNA 125b and let7a levels in liver tissue[2].
Chemical Information
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CAS No. 17034-35-4
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Appearance Solid
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Masse moléculaire 3055.41
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Formule C130H220N44O41
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Color White to off-white
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Sequence
His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-Asp-Ser-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-Val-NH2
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Sequence Shortening
HSDGTFTSELSRLRDSARLQRLLQGLV-NH2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvant et solubilité
DMSO : 66.67 mg/mL (21.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (282 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Katharina Schnabl, et al. Secretin as a Satiation Whisperer With the Potential to Turn into an Obesity-curbing Knight. Endocrinology. 2021 Sep 1;162(9):bqab113. [Content Brief]
[2]. Shannon Glaser, et al. Secretin stimulates biliary cell proliferation by regulating expression of microRNA 125b and microRNA let7a in mice. Gastroenterology. 2014 Jun;146(7):1795-808.e12. [Content Brief]
[3]. G Alpini, et al. Morphological, molecular, and functional heterogeneity of cholangiocytes from normal rat liver. Gastroenterology. 1996 May;110(5):1636-43. [Content Brief]
[4]. Shannon Glaser, et al. Knockout of secretin receptor reduces large cholangiocyte hyperplasia in mice with extrahepatic cholestasis induced by bile duct ligation. Hepatology. 2010 Jul;52(1):204-14. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.3273 mL | 1.6364 mL | 3.2729 mL | 8.1822 mL |
| 5 mM | 0.0655 mL | 0.3273 mL | 0.6546 mL | 1.6364 mL | |
| 10 mM | 0.0327 mL | 0.1636 mL | 0.3273 mL | 0.8182 mL | |
| 15 mM | 0.0218 mL | 0.1091 mL | 0.2182 mL | 0.5455 mL | |
| 20 mM | 0.0164 mL | 0.0818 mL | 0.1636 mL | 0.4091 mL |
Secretin (swine) Related Classifications
HY-109538 Related Classifications
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