2. GPCR/G Protein
  3. Secretin Receptor
  4. Secretin (swine)

Secretin (swine), a neuroendocrine hormone, is the first hormone to be identifie and is secreted by S cells that are localized primarily in the mucosa of the duodenum. Secretin also is a 27-amino acid peptide, which acts on secretin receptors. Secretin is expressed by cells in all mature enteroendocrine cell subsets and can be prompted by fatty acids. Secretin stimulates the secretion of pancreatic water and bicarbonate. Secretin exerts various effects in organs, can be used for the research of digestive system, central nervous system and energy metabolism.

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Secretin (swine) Chemical Structure

Secretin (swine) Chemical Structure

CAS No. : 17034-35-4

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Secretin (swine) Related Antibodies

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Description

Secretin (swine), a neuroendocrine hormone, is the first hormone to be identifie and is secreted by S cells that are localized primarily in the mucosa of the duodenum. Secretin also is a 27-amino acid peptide, which acts on secretin receptors. Secretin is expressed by cells in all mature enteroendocrine cell subsets and can be prompted by fatty acids. Secretin stimulates the secretion of pancreatic water and bicarbonate. Secretin exerts various effects in organs, can be used for the research of digestive system, central nervous system and energy metabolism[1][2].

In Vitro

Secretin (swine) (10−7M, 10−6M; 24 to 72 h and 7 days) stimulates biliary growth by interaction with secretin receptors (SR) and knockout of SR reduces biliary proliferation by downregulating cAMP dependent signaling[2].
Secretin (10−7M, 10−6M; 24 to 72 h and 7 days) increases the proliferation in human HIBEpiC and large murine cholangiocyte lines[2][3][4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Secretin (swine) Related Antibodies
In Vivo

Secretin (swine) (2.5 nM/kg, BW/day, osmotic minipumps, for 1 week) stimulates biliary cell proliferation by regulating expression of microRNA 125b and microRNA let7a in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sct＋/－mice[2]
Dosage: 2.5 nM/kg
Administration: 2.5 nM/kg, BW/day, osmotic minipumps, for 1 week
Result: Increased in supernatants from cholangiocytes and S cells and in serum and bile following BDL in control mice.
Had low IBDM, reduced proliferation, and reduced production of vascular endothelial growth factor A (VEGFA) and nerve growth factor (NGF) in BDL Sct＋/－mice.
Regulated VEGF and NGF expression that negatively correlated with microRNA 125b and let7a levels in liver tissue[2].
Molecular Weight

3055.41

Formula

C130H220N44O41
CAS No.
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Purity & Documentation
References
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Secretin (swine) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Secretin (swine)17034-35-4Secretin ReceptorSCTRneuroendocrine hormoneS cellspeptidesecretin receptorsenteroendocrine celldigestive systemcentral nervous systemenergy metabolismInhibitorinhibitorinhibit

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