1. Peptides

Secretin (28-54), human (Synonyms: Human secretin)

Cat. No.: HY-P1465
Handling Instructions

Secretin (28-54), human is a 27-amino acid residue C-terminally amidated peptide, which acts on secretin receptors. Sequence: His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-Glu-Gly-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-Val-NH2;HSDGTFTSELSRLREGARLQRLLQGLV-NH2.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Secretin (28-54), human Chemical Structure

Secretin (28-54), human Chemical Structure

CAS No. : 108153-74-8

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Secretin (28-54), human is a 27-amino acid residue C-terminally amidated peptide, which acts on secretin receptors. Sequence: His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-Glu-Gly-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-Val-NH2;HSDGTFTSELSRLREGARLQRLLQGLV-NH2.

IC50 & Target

Human secretin receptor[1]

In Vitro

Secretin (28-54), human (Human secretin) binds to secretin receptors on the presynaptic membrane or on the Purkinje cell membrane[1]. Secretin (28-54), human (Human secretin) enhances the secretion of bicarbonate, enzymes, and K+ from the pancreas.Secretin (28-54), human is expressed in the hypothalamus and pituitary gland, and Secretin (28-54), human inhibits adrenocorticotropic hormone (ACTH) release.Secretin (28-54), human selectively depresses the glucocorticoid response to ACTH of dispersed zona fasciculata-reticularis (ZF/R) cells[2]. Secretin (28-54), human (Human secretin) is a 27-amino acid peptide and is the active form of pro-secretin, which is known as a preprohormone and is synthesized as a larger precursor like other regulatory peptides. Secretin is secreted by S cells in the small intestine and affects the function of a number of organ systems. Secretin receptors (SR) are expressed in the basolateral domain of several cell types. Secretin is a member of the secretin-glucagon family and is secreted by S cells of the duodenum in the crypts of Lieberkühn. Secretin affects the function of a number of organ systems and cell types. Secretin exerts its biological effects through G-protein coupled secretin receptors (SR), which are expressed in the basolateral domain of several cells. In addition to regulating the pH of the duodenal content by the control of gastric acid secretion, secretin regulates the secretion of bicarbonate ions into the duodenum from the epithelia lining the pancreatic and biliary ducts[3].

Clinical Trial
Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
References
Molecular Weight

3039.46

Formula

C₁₃₀H₂₂₀N₄₄O₄₀

CAS No.

108153-74-8

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Secretin (28-54), human
Cat. No.:
HY-P1465
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Secretin (28-54), human

Cat. No.: HY-P1465