1. Antibody-drug Conjugate/ADC Related
  2. ADC Cytotoxin
  3. Maytansinoid DM4

Maytansinoid DM4 

Cat. No.: HY-100503
Handling Instructions

Maytansinoid DM4 is a thiol-containing maytansine derivative with highly potent cytotoxicity. Maytansinoid DM4 can be used as a cytotoxic moiety of ADC.

For research use only. We do not sell to patients.

Maytansinoid DM4 Chemical Structure

Maytansinoid DM4 Chemical Structure

CAS No. : 799840-96-3

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Description

Maytansinoid DM4 is a thiol-containing maytansine derivative with highly potent cytotoxicity. Maytansinoid DM4 can be used as a cytotoxic moiety of ADC[1][2].

IC50 & Target[1][2]

Maytansinoids

 

In Vitro

Maytansine is a natural benzoansamacrolide product isolated from the bark of the African shrub Maytenus ovatus. Maytansine binds to the same site on tubulin as the vinca alkaloids, with similar in vitro inhibition constants, but is a more-potent cytotoxin[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

794.39

Formula

C₃₉H₅₆ClN₃O₁₀S

CAS No.

799840-96-3

SMILES

C[[email protected]]1([[email protected]](CC(N(C(C=C(C2)C=C3OC)=C3Cl)C)=O)OC([[email protected]](C)N(C)C(CCC(C)(S)C)=O)=O)[[email protected]@](C(C)([[email protected]](OC4=O)([H])C[[email protected]]([[email protected]@H](/C=C/C=C2\C)OC)(N4)O)C)([H])O1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Maytansinoid DM4Maytansinoid DM 4Maytansinoid DM-4ADC CytotoxinADCthiolmaytansinecytotoxintubulinanti-cancerInhibitorinhibitorinhibit

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Maytansinoid DM4
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HY-100503
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