Tubulin/JAK2-IN-1

Cat. No.: HY-156423 Purity: 99.14%: Data Sheet
COA

SDS
Handling Instructions
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Tubulin/JAK2-IN-1 (compound 7g) is a dual inhibitor of Janus kinase 2 (JAK2) and microtubule. Tubulin/JAK2-IN-1 has potent antiproliferative activity against the cancer cells.

For research use only. We do not sell to patients.

Tubulin/JAK2-IN-1 Chemical Structure

CAS No. : 2933938-46-4

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

Tubulin/JAK2-IN-1 (compound 7g) is a dual inhibitor of Janus kinase 2 (JAK2) and microtubule. Tubulin/JAK2-IN-1 has potent antiproliferative activity against the cancer cells^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	0.075 μM Compound: 7g	Antiproliferative activity against human A2780 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human A2780 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
A2780/Taxol	IC₅₀	0.02 μM Compound: 7g	Antiproliferative activity against human A2780T cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human A2780T cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
A549	IC₅₀	0.008 μM Compound: 7g	Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
ARPE-19	IC₅₀	5034 nM Compound: 7g	Cytotoxicity against human ARPE-19 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Cytotoxicity against human ARPE-19 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
BXPC-3	IC₅₀	0.011 μM Compound: 7g	Antiproliferative activity against human BXPC-3 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human BXPC-3 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
CHO	IC₅₀	0.024 μM Compound: 7g	Antiproliferative activity against Chinese hamster CHO cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against Chinese hamster CHO cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
CHO-K1	IC₅₀	0.13 μM Compound: 7g	Antiproliferative activity against Chinese hamster CHO-K1 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against Chinese hamster CHO-K1 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
COLO 205	IC₅₀	12.1 nM Compound: 7g	Cytotoxicity against human COLO 205 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Cytotoxicity against human COLO 205 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
CWR22R	IC₅₀	12.4 nM Compound: 7g	Cytotoxicity against human 22Rv1 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Cytotoxicity against human 22Rv1 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
HCT-8	IC₅₀	0.034 μM Compound: 7g	Antiproliferative activity against human HCT-8 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human HCT-8 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
HT-29	IC₅₀	0.027 μM Compound: 7g	Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
HaCaT	IC₅₀	449.6 nM Compound: 7g	Cytotoxicity against human HaCaT cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Cytotoxicity against human HaCaT cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
HeLa	IC₅₀	0.015 μM Compound: 7g	Antiproliferative activity against human HeLa cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
HepG2	IC₅₀	51.8 nM Compound: 7g	Cytotoxicity against human HepG2 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
KP-4	IC₅₀	0.013 μM Compound: 7g	Antiproliferative activity against human KP-4 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human KP-4 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
L02	IC₅₀	338.7 nM Compound: 7g	Cytotoxicity against human L02 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Cytotoxicity against human L02 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
MCF7	IC₅₀	0.018 μM Compound: 7g	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
NCI/ADR-RES	IC₅₀	0.064 μM Compound: 7g	Antiproliferative activity against human MCF7ADR cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human MCF7ADR cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
PC-3	IC₅₀	0.224 μM Compound: 7g	Antiproliferative activity against human PC-3 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human PC-3 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]

Molecular Weight

416.43

Formula

C₂₂H₂₀N₆O₃

CAS No.

2933938-46-4

Appearance

Solid

Color

Light yellow to yellow

SMILES

COC1=C(OC)C(OC)=CC(C2=NC=CC3=NC(NC4=CC=CC5=C4C=CN5)=NN23)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (240.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4014 mL	12.0068 mL	24.0136 mL
5 mM	0.4803 mL	2.4014 mL	4.8027 mL
10 mM	0.2401 mL	1.2007 mL	2.4014 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.14%

Select Batch:

Data Sheet (277 KB) SDS (251 KB)

COA (258 KB) HNMR (230 KB) LCMS (99 KB)

Handling Instructions (2659 KB)

References

[1]. Li Chen, et al. Design, Synthesis, and Antitumor Efficacy of Substituted 2-Amino[1,2,4]triazolopyrimidines and Related Heterocycles as Dual Inhibitors for Microtubule Polymerization and Janus Kinase 2. J Med Chem. 2023. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4014 mL	12.0068 mL	24.0136 mL	60.0341 mL
	5 mM	0.4803 mL	2.4014 mL	4.8027 mL	12.0068 mL
	10 mM	0.2401 mL	1.2007 mL	2.4014 mL	6.0034 mL
	15 mM	0.1601 mL	0.8005 mL	1.6009 mL	4.0023 mL
	20 mM	0.1201 mL	0.6003 mL	1.2007 mL	3.0017 mL
	25 mM	0.0961 mL	0.4803 mL	0.9605 mL	2.4014 mL
	30 mM	0.0800 mL	0.4002 mL	0.8005 mL	2.0011 mL
	40 mM	0.0600 mL	0.3002 mL	0.6003 mL	1.5009 mL
	50 mM	0.0480 mL	0.2401 mL	0.4803 mL	1.2007 mL
	60 mM	0.0400 mL	0.2001 mL	0.4002 mL	1.0006 mL
	80 mM	0.0300 mL	0.1501 mL	0.3002 mL	0.7504 mL
	100 mM	0.0240 mL	0.1201 mL	0.2401 mL	0.6003 mL

Tubulin/JAK2-IN-1 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin/JAK2-IN-12933938-46-4Microtubule/TubulinJAKJanus kinaseTubulin/JAK2-IN-1 inhibitorAntitumorInhibitorinhibitorinhibit

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Tubulin/JAK2-IN-1

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Tubulin/JAK2-IN-1 Related Antibodies

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Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Tubulin/JAK2-IN-1 Related Classifications

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Customer Review

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SAFETY DATA SHEET (SDS)

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