Cat. No.: HY-156423

Tubulin/JAK2-IN-1

Name: Tubulin/JAK2-IN-1
Brand: MedChemExpress
SKU: HY-156423
Price: 450.00 USD
Availability: InStock
Rating: 5 (1 reviews)

Customer Review

Based on 1 Customer Validation

Tubulin/JAK2-IN-1 (compound 7g) is a dual inhibitor of Janus kinase 2 (JAK2) and microtubule. Tubulin/JAK2-IN-1 has potent antiproliferative activity against the cancer cells.

For research use only. We do not sell to patients.

Purity: 99.14%
CAS No.: 2933938-46-4
Formula: C₂₂H₂₀N₆O₃
Molecular Weight:416.43

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Tubulin/JAK2-IN-1 Chemical Structure

CAS No.: 2933938-46-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Tubulin/JAK2-IN-1 (compound 7g) is a dual inhibitor of Janus kinase 2 (JAK2) and microtubule. Tubulin/JAK2-IN-1 has potent antiproliferative activity against the cancer cells^[1].

All JAK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	0.075 μM Compound: 7g	Antiproliferative activity against human A2780 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human A2780 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
A2780/Taxol	IC₅₀	0.02 μM Compound: 7g	Antiproliferative activity against human A2780T cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human A2780T cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
A549	IC₅₀	0.008 μM Compound: 7g	Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
ARPE-19	IC₅₀	5034 nM Compound: 7g	Cytotoxicity against human ARPE-19 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Cytotoxicity against human ARPE-19 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
BXPC-3	IC₅₀	0.011 μM Compound: 7g	Antiproliferative activity against human BXPC-3 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human BXPC-3 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
CHO	IC₅₀	0.024 μM Compound: 7g	Antiproliferative activity against Chinese hamster CHO cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against Chinese hamster CHO cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
CHO-K1	IC₅₀	0.13 μM Compound: 7g	Antiproliferative activity against Chinese hamster CHO-K1 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against Chinese hamster CHO-K1 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
COLO 205	IC₅₀	12.1 nM Compound: 7g	Cytotoxicity against human COLO 205 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Cytotoxicity against human COLO 205 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
CWR22R	IC₅₀	12.4 nM Compound: 7g	Cytotoxicity against human 22Rv1 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Cytotoxicity against human 22Rv1 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
HaCaT	IC₅₀	449.6 nM Compound: 7g	Cytotoxicity against human HaCaT cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Cytotoxicity against human HaCaT cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
HCT-8	IC₅₀	0.034 μM Compound: 7g	Antiproliferative activity against human HCT-8 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human HCT-8 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
HeLa	IC₅₀	0.015 μM Compound: 7g	Antiproliferative activity against human HeLa cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
HepG2	IC₅₀	51.8 nM Compound: 7g	Cytotoxicity against human HepG2 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
HT-29	IC₅₀	0.027 μM Compound: 7g	Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
KP-4	IC₅₀	0.013 μM Compound: 7g	Antiproliferative activity against human KP-4 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human KP-4 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
L02	IC₅₀	338.7 nM Compound: 7g	Cytotoxicity against human L02 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Cytotoxicity against human L02 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
MCF7	IC₅₀	0.018 μM Compound: 7g	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
NCI/ADR-RES	IC₅₀	0.064 μM Compound: 7g	Antiproliferative activity against human MCF7ADR cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human MCF7ADR cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
PC-3	IC₅₀	0.224 μM Compound: 7g	Antiproliferative activity against human PC-3 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human PC-3 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]

Chemical Information

CAS No. 2933938-46-4
Appearance Solid
Molecular Weight 416.43
Formula C₂₂H₂₀N₆O₃
Color Light yellow to yellow
SMILES

COC1=C(OC)C(OC)=CC(C2=NC=CC3=NC(NC4=CC=CC5=C4C=CN5)=NN23)=C1
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (240.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.4014 mL

12.0068 mL

24.0136 mL

5 mM

0.4803 mL

2.4014 mL

4.8027 mL

10 mM

0.2401 mL

1.2007 mL

2.4014 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li Chen, et al. Design, Synthesis, and Antitumor Efficacy of Substituted 2-Amino[1,2,4]triazolopyrimidines and Related Heterocycles as Dual Inhibitors for Microtubule Polymerization and Janus Kinase 2. J Med Chem. 2023. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.4014 mL	12.0068 mL	24.0136 mL	60.0341 mL
	5 mM	0.4803 mL	2.4014 mL	4.8027 mL	12.0068 mL
	10 mM	0.2401 mL	1.2007 mL	2.4014 mL	6.0034 mL
	15 mM	0.1601 mL	0.8005 mL	1.6009 mL	4.0023 mL
	20 mM	0.1201 mL	0.6003 mL	1.2007 mL	3.0017 mL
	25 mM	0.0961 mL	0.4803 mL	0.9605 mL	2.4014 mL
	30 mM	0.0800 mL	0.4002 mL	0.8005 mL	2.0011 mL
	40 mM	0.0600 mL	0.3002 mL	0.6003 mL	1.5009 mL
	50 mM	0.0480 mL	0.2401 mL	0.4803 mL	1.2007 mL
	60 mM	0.0400 mL	0.2001 mL	0.4002 mL	1.0006 mL
	80 mM	0.0300 mL	0.1501 mL	0.3002 mL	0.7504 mL
	100 mM	0.0240 mL	0.1201 mL	0.2401 mL	0.6003 mL

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Tubulin/JAK2-IN-1

All JAK Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Tubulin/JAK2-IN-1 Related Classifications

HY-156423 Related Classifications

Bioz