Microtubule/Tubulin Degrader

PROTAC Tubulin degrader-2 is a cereblon (CRBN)-dependent α/β-tubulin PROTAC degrader with DC₅₀ values of 1.73 μM and 1.38 μM. PROTAC Tubulin degrader-2 can inhibit cancer cells proliferation and migration. PROTAC Tubulin degrader-2 can induce G2/M arrest, apoptosis, ROS accumulation. PROTAC Tubulin degrader-2 can be used for the research of cancer, such as non-small-cell lung cancer.

Tubulin degrader 1, a derivative of BML284 (HY-19987), is an orally active Tubulin degrader with anti-tumor cell proliferation activity. Tubulin degrader 1 binds to the colchicine-binding site of β-tubulin, inhibits tubulin polymerization and promotes tubulin degradation. Tubulin degrader 1 inhibits microtubule polymerization, induces G2/M cell cycle arrest and apoptosis. Tubulin degrader 1 suppresses tumor growth in ovarian cancer xenograft models, induces anti-proliferative activity against tumor cells and overcomes multidrug resistance. Tubulin degrader 1 can be used in research related to various cancers including ovarian cancer.

PROTAC tubulin-Degrader-1 is a α/β/β3-tubulin PROTAC degrader. PROTAC tubulin-Degrader-1 exhibits potent anti-proliferative activity against multiple human tumor cell lines. PROTAC tubulin-Degrader-1 induces G2/M phase arrest and apoptosis and inhibits colony formation in A549 and A549/Taxol cells. PROTAC tubulin-Degrader-1demonstrates potent anti-tumor efficacy in A549 and A549/Taxol (Taxol-resistant) xenograft model. PROTAC tubulin-Degrader-1 can be used for the study of non-small cell lung cancer (NSCLC). (Pink: Tubulin ligand (HY-N2146), Blue: CRBN Ligand (HY-10984), Black: Linker (HY-N6056)).